From the Guidelines
The recommended starting dose of Effexor (venlafaxine) for adults is 37.5 mg once or twice daily. This dosage is based on the most recent and highest quality study available, which provides guidelines for the pharmacological management of neuropathic pain 1.
Key Considerations
- The dose can be increased by 75 mg each week, with a maximum dosage of 225 mg/d, and the treatment should be continued for 4-6 weeks to assess its efficacy 1.
- It is essential to consider lower starting dosages and slower titration in geriatric patients, as they may be more sensitive to the medication's effects.
- The medication should be taken consistently, and any discontinuation should be done gradually under medical supervision to avoid withdrawal symptoms.
Important Details
- Venlafaxine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI), which works by increasing the levels of serotonin and norepinephrine in the brain to regulate mood and reduce anxiety.
- The medication's efficacy and tolerability may vary among individuals, and the dosage may need to be adjusted based on clinical response and tolerability.
- It is crucial to follow the recommended dosage and treatment duration to ensure the medication's effectiveness and minimize potential side effects.
From the FDA Drug Label
The recommended starting dose for venlafaxine tablets, USP is 75 mg/day, administered in two or three divided doses, taken with food. The recommended starting dose of Effexor (venlafaxine) for adults is 75 mg/day, administered in two or three divided doses, taken with food 2.
From the Research
Recommended Starting Dose of Effexor (Venlafaxine) for Adults
The recommended starting dose of Effexor (venlafaxine) for adults can vary depending on the specific condition being treated and the formulation of the medication.
- For major depressive disorder, the starting dose is typically 75 mg/day, given as a single dose or divided into two or three doses per day 3, 4.
- The dose can be increased as needed and tolerated, up to a maximum dose of 225 mg/day for the extended-release formulation 3, 5.
- It's worth noting that the efficacy of venlafaxine has been demonstrated at doses ranging from 75 to 225 mg/day, and the medication has been shown to be effective in reducing symptoms of depression in patients with major depressive disorder 6.
Key Considerations
When determining the starting dose of Effexor (venlafaxine) for adults, the following factors should be considered:
- The patient's medical history and current health status
- The severity of their depressive symptoms
- Their ability to tolerate the medication
- The potential for interactions with other medications they are taking
- The need for dose adjustments based on the patient's response to treatment and any adverse effects they may experience 4, 7.
Dose Adjustments
Dose adjustments may be necessary to achieve the optimal therapeutic effect and minimize adverse effects.