From the FDA Drug Label
Take apixaban tablets twice every day with or without food.
Apixaban can be taken with or without food. It is recommended to take apixaban tablets twice every day as prescribed by your doctor, regardless of food intake. 1
From the Research
Apixaban can be taken with or without food, as food does not have a clinically meaningful impact on its bioavailability. This oral anticoagulant medication does not have any food requirements, making it convenient for patients to take at their prescribed times regardless of meals 2. The standard dosing for most patients is 5 mg twice daily, though some patients may receive 2.5 mg twice daily based on age, weight, or kidney function. It's essential to take apixaban at approximately the same times each day to maintain consistent blood levels of the medication. If you miss a dose, take it as soon as you remember on the same day, but never take a double dose to make up for a missed one. Unlike warfarin, apixaban doesn't require routine blood monitoring or dietary restrictions. The medication works by inhibiting Factor Xa, a key component in the blood clotting process, which helps prevent harmful blood clots from forming while allowing normal clotting for injuries. Always store apixaban at room temperature and keep it in its original container to protect it from moisture.
Some key points to consider when taking apixaban include:
- The absolute oral bioavailability of apixaban is approximately 50% 2
- Apixaban exposure increases dose proportionally for oral doses up to 10 mg 2
- The half-life of apixaban is approximately 12 hours, and elimination occurs via multiple pathways including metabolism, biliary excretion, and direct intestinal excretion 2
- Apixaban has limited clinically relevant interactions with most commonly prescribed medications, allowing for fixed dosages without the need for therapeutic drug monitoring 2
It's crucial to follow the prescribed dosage and administration instructions for apixaban to ensure its effectiveness and minimize potential side effects. If you have any questions or concerns about taking apixaban, consult your healthcare provider for personalized guidance.