From the Guidelines
The best material for wrinkle patches is autologous platelet concentrates, which have been shown to promote collagen production, improve skin texture, and reduce the appearance of fine lines and wrinkles. According to a study published in 2025 1, autologous platelet concentrates have regenerative properties that can stimulate tissue repair and skin rejuvenation. Another study from 2025 1 found that plasma gel injection, which contains autologous growth factors, can produce significant esthetic correction of facial wrinkles and tear trough deformity.
Some key benefits of using autologous platelet concentrates for wrinkle patches include:
- Promoting collagen production and improving skin texture
- Reducing the appearance of fine lines and wrinkles
- Providing a minimally invasive and cost-effective treatment option
- Being a safe and well-tolerated procedure with minimal risk of adverse effects
It's worth noting that other materials, such as silicone and hyaluronic acid, may also be effective for wrinkle patches, but the most recent and highest-quality evidence supports the use of autologous platelet concentrates. As stated in a study from 2025 1, the use of autologous platelet concentrates in facial esthetics is expected to continue growing due to its promising therapeutic modality.
Overall, autologous platelet concentrates are the best material for wrinkle patches due to their ability to promote collagen production, improve skin texture, and reduce the appearance of fine lines and wrinkles.
From the Research
Materials for Wrinkle Patches
The best material for wrinkle patches can vary depending on the desired outcome and the individual's skin type. However, based on the available studies, some materials have shown promising results:
- Dissolving microneedles loaded with retinyl retinoate and ascorbic acid have demonstrated statistically significant differences in wrinkle improvement 2
- Soluble hyaluronic acid (HA) microneedle patches, alone or in combination with adenosine wrinkle cream, have shown significant improvements in facial wrinkles 3
- Argireline, a synthetic hexapeptide, has been shown to reduce the degree of facial wrinkles in Chinese subjects 4
- Collagen and vitamin C supplements, with or without hyaluronic acid, have been found to improve skin density, texture, and reduce the severity of wrinkles 5
- Retinol and retinoic acid have been compared in their effects on human skin, with both showing increases in epidermal thickness and improvements in skin appearance 6
Key Findings
Some key findings from the studies include:
- The use of dissolving microneedles and soluble HA microneedle patches has been shown to be safe and effective in improving facial wrinkles
- The combination of microneedle patches with wrinkle cream can enhance skin rejuvenation
- Dietary supplements such as collagen and vitamin C can improve skin parameters, including density and texture
- Topical application of retinol can significantly affect both cellular and molecular properties of the epidermis and dermis, leading to improved skin appearance
Considerations
When considering the best material for wrinkle patches, it's essential to take into account individual skin types and needs, as well as the desired outcome. The studies suggest that a combination of materials and treatments may be more effective than a single approach 2, 3, 6. Additionally, the safety and efficacy of any material or treatment should be carefully evaluated before use 2, 3, 4.