From the Research
Trazodone and doxazosin can generally be taken together, but this combination requires caution and medical supervision due to the potential risk of orthostatic hypotension. Both medications can lower blood pressure, so taking them together may increase the risk of a sudden drop in blood pressure when standing up, which can cause dizziness, lightheadedness, or fainting 1. This risk is particularly important during the first few days of treatment or when dosages are increased. If you're prescribed both medications, it's advisable to monitor your blood pressure regularly and rise slowly from sitting or lying positions, especially when first starting either medication.
Key Considerations
- Trazodone is typically used for depression or insomnia, while doxazosin treats high blood pressure or enlarged prostate symptoms, so the benefits of this combination may outweigh the risks for some patients 2.
- However, your doctor should evaluate your specific health conditions, other medications you're taking, and individual risk factors before recommending this combination.
- Always inform your healthcare provider about all medications you're taking to avoid potentially harmful interactions.
- The combination of trazodone and other medications that lower blood pressure, such as doxazosin, may increase the risk of orthostatic hypotension, as seen in studies with other medications like clonidine and phenothiazines 3, 4.
Monitoring and Precautions
- Monitor blood pressure regularly, especially during the initial treatment period or when adjusting dosages.
- Rise slowly from sitting or lying positions to minimize the risk of dizziness or fainting.
- Be aware of the potential for increased risk of orthostatic hypotension when taking trazodone and doxazosin together, and take precautions to mitigate this risk.