From the Guidelines
Tetrahydrocannabinol (THC) can stay in fat cells for an extended period, with the exact duration varying based on individual factors, but it is known that THC is highly lipid soluble, resulting in adipose tissue accumulation, and can lead to a gradual release of stored THC after periods of adipose breakdown. The storage of THC in fat cells is influenced by several factors, including:
- Frequency of use
- Body fat percentage
- Metabolism rate
- Hydration levels As noted in the study by 1, most cannabinoids, including THC, are highly lipid soluble, resulting in adipose tissue accumulation, which can lead to a gradual release of stored THC after periods of adipose breakdown. While there is no specific duration mentioned in the study, it highlights the importance of considering the pharmacokinetics and pharmacodynamics of THC, especially in adults with cancer who may be using cannabis products. The study also mentions that the onset of oral THC may be ≥1 hour after ingestion, and dosing should start at the lowest possible dose and be increased gingerly with sufficient time between doses to gauge effects 1. It is essential to consider these factors when assessing how long THC stays in fat cells, as individual variations can significantly impact the duration of storage and release.
From the Research
Duration of THC in Fat Cells
- The duration of Tetrahydrocannabinol (THC) in fat cells is influenced by its high lipid solubility, which allows it to be rapidly taken up by fat tissue 2.
- The plasma half-life of THC is 1 to 3 days in occasional users and 5 to 13 days in chronic users, indicating that THC can stay in the system for an extended period 2.
- THC is stored in fat cells and can be released back into the bloodstream, potentially leading to prolonged detection times in drug tests 3.
Factors Affecting THC Duration in Fat Cells
- Exercise can increase plasma THC concentrations in regular cannabis users by releasing dormant THC from fat stores 3.
- Fasting may not significantly alter plasma cannabinoid levels, but can increase fat utilization and potentially release THC from fat cells 3.
- The frequency and amount of cannabis use can impact the duration of THC in fat cells, with chronic users potentially having longer detection times 2.
Implications for Drug Testing
- The interpretation of blood THC levels in roadside and workplace tests may be complicated by recent exercise or other factors that can release THC from fat stores 3.
- The use of chemical adsorbents, such as activated charcoal, may interrupt or restrict the enterohepatic circulation of THC and its metabolites, potentially affecting detection times 4.