From the Guidelines
The recommended dose of dicyclomine is 1-3 mg/kg/day, as stated in the most relevant study 1. This dose is based on the guidelines of care for the management of atopic dermatitis, which provides a range of 1-3 mg/kg/day for dicyclomine. Some key points to consider when administering dicyclomine include:
- Starting at the lower end of the dosing range and titrating up as needed to control symptoms while minimizing side effects
- Being aware of common side effects such as dry mouth, blurred vision, urinary retention, and constipation
- Using caution in patients with glaucoma, urinary retention, gastrointestinal obstruction, or severe ulcerative colitis, as dicyclomine may exacerbate these conditions It's also important to note that dicyclomine works by relaxing smooth muscle in the gastrointestinal tract, thereby reducing spasms and associated pain. Other studies, such as 1, 1, 1, 1, 1, 1, 1, and 1, provide different dosing recommendations, but these are not directly relevant to the question of dicyclomine dosing. Therefore, the most appropriate dose of dicyclomine is 1-3 mg/kg/day, as recommended in the most relevant study 1.
From the FDA Drug Label
Reproduction studies have been performed in rats and rabbits at doses up to 33 times the maximum recommended human dose based on 160 mg/day (3 mg/kg)
The recommended dose of dicyclomine per kilogram is 3 mg/kg per day, based on a maximum recommended human dose of 160 mg/day 2.
From the Research
Dose of Dicyclomine per kg
- The recommended dose of dicyclomine per kilogram is not explicitly stated in most of the provided studies, as they focus on various aspects such as drug interactions, thrombosis, and treatment of infantile colics rather than dosing guidelines.
- However, one study 3 mentions the use of dicyclomine hydrochloride at a dose of 3 mg/kg/day for the treatment of severe infantile colics, suggesting a specific dosage per kilogram for this particular condition.
- It is essential to note that dosing recommendations can vary based on the condition being treated, age of the patient, and other factors, and should always be determined by a healthcare professional.
- There is no direct information on the dose of dicyclomine per kg for other conditions or in other age groups in the provided studies 4, 5, 6, 7.