What is the proper dosage and administration of Hidrasec (Hyoscyamine) for infants, children, and adults?

From the FDA Drug Label

DOSAGE AND ADMINISTRATION HYOSYNE ORAL DROPS (Hyoscyamine Sulfate Oral Solution) Dosage may be adjusted according to the conditions and severity of symptoms. Measure dosage very carefully. Adults and pediatric patients 12 years of age and older: 1 to 2 mL every four hours or as needed. Do not exceed 12 mL in 24 hours Pediatric patients 2 to under 12 years of age: 1/4 to 1 mL every four hours or as needed. Do not exceed 6 mL in 24 hours. Pediatric patients under 2 years of age: The following dosage guide is based upon body weight. The doses may be repeated every four hours or as needed. Body Weight | Usual Dose | Do Not Exceed In 24 Hours 3.4 kg (7.5 lb.) | 4 drops | 24 drops 5 kg (11 lb.) | 5 drops | 30 drops 7 kg (15 lb.) | 6 drops | 36 drops 10 kg (22 lb.) | 8 drops | 48 drops

The proper dosage and administration of Hidrasec (Hyoscyamine) for:

• Infants (under 2 years of age): The dosage is based on body weight, with the following guide:
  • 3.4 kg (7.5 lb): 4 drops, do not exceed 24 drops in 24 hours
  • 5 kg (11 lb): 5 drops, do not exceed 30 drops in 24 hours
  • 7 kg (15 lb): 6 drops, do not exceed 36 drops in 24 hours
  • 10 kg (22 lb): 8 drops, do not exceed 48 drops in 24 hours
• Children (2 to under 12 years of age): 1/4 to 1 mL every four hours or as needed, do not exceed 6 mL in 24 hours
• Adults: 1 to 2 mL every four hours or as needed, do not exceed 12 mL in 24 hours 1

From the Research

The proper dosage and administration of Hidrasec (Hyoscyamine) for infants, children, and adults should be individualized based on the patient's age, size, and level of organ maturity, with careful consideration of the medication's pharmacokinetic parameters and potential side effects, as recommended by the most recent and highest quality study available 2.

Key Considerations for Administration

• For infants and children, the dosage should be based on the child's age, swallowing ability, ease of administration, and accessibility of the product, with consideration of the child's preference for formulations and flavors 2.
• For adults, the typical dose of Hyoscyamine is 0.125-0.25 mg every 4 hours as needed, not exceeding 1.5 mg in 24 hours.
• For children 2-12 years, the dose is typically 0.0625-0.125 mg every 4 hours as needed, while it's generally not recommended for infants under 2 years without specific medical guidance.

Important Safety Information

• Hyoscyamine can cause serious side effects, including dry mouth, blurred vision, and urinary retention, and should be used with caution in patients with certain medical conditions, such as glaucoma, benign prostatic hyperplasia, and gastroesophageal reflux disease.
• The medication should be taken as prescribed by a healthcare provider, with individual circumstances requiring dosage adjustments, and with careful monitoring for potential side effects and interactions with other medications.

Administration Guidelines

• The medication should be administered orally, with or without food, and with a full glass of water.
• The dosage should be titrated to the minimum effective dose to minimize the risk of side effects and maximize the therapeutic benefit.
• Patients should be advised to report any adverse effects or concerns to their healthcare provider promptly.