From the Research
Yes, lactated Ringer's (LR) solution can be safely administered to pregnant women, as it is considered a preferred intravenous fluid for pregnant patients requiring fluid resuscitation or maintenance therapy 1. LR is an isotonic crystalloid solution containing sodium, potassium, calcium, chloride, and lactate, which closely resembles the electrolyte composition of human plasma. During pregnancy, LR is particularly advantageous because it helps maintain maternal hemodynamics without causing significant fluid shifts that could compromise placental perfusion.
The lactate in the solution is metabolized by the liver to bicarbonate, which can help correct mild acidosis if present. Pregnant women often require fluid administration during labor, cesarean delivery, or to treat conditions like hyperemesis gravidarum or dehydration. The typical administration rate varies based on clinical need, ranging from maintenance rates of 125 ml/hour to bolus administration of 500-1000 ml for hypotension or hypovolemia.
Healthcare providers should monitor fluid status carefully, as pregnant women are susceptible to both dehydration and fluid overload due to physiological changes in pregnancy. A recent study published in 2025 found that a hospital-wide policy to administer lactated Ringer's solution rather than normal saline did not result in a significantly lower incidence of death or readmission to the hospital within 90 days after the index admission 1.
Some older studies have also investigated the effects of lactated Ringer's solution in pregnant women, including its impact on fetal electrolyte and acid-base responses 2, and its effect on maternal capillary blood glucose before elective cesarean section 3. However, the most recent and highest quality study, which is the 2025 study, supports the safe use of lactated Ringer's solution in pregnant women 1.
Key points to consider when administering lactated Ringer's solution to pregnant women include:
- Monitoring fluid status carefully to avoid dehydration and fluid overload
- Using the solution for fluid resuscitation or maintenance therapy as needed
- Being aware of the potential effects on maternal hemodynamics and placental perfusion
- Considering the lactate in the solution, which is metabolized by the liver to bicarbonate, and can help correct mild acidosis if present.