From the Research
Approximately 0% of men develop lipidemias when using 50 mg testosterone gel, as there were no significant changes in the lipid profile reported in the study. This side effect manifests as changes in cholesterol metabolism, typically with decreases in HDL ("good") cholesterol and potential increases in LDL ("bad") cholesterol or triglycerides. Men using testosterone gel should have their lipid profiles monitored regularly, typically at baseline, 3 months after starting therapy, and then annually. These lipid changes occur because testosterone affects liver metabolism of lipoproteins and can alter the body's cholesterol balance. The risk is higher in men with pre-existing lipid abnormalities, obesity, or metabolic syndrome. Patients using testosterone gel should maintain a heart-healthy diet, regular exercise, and consider lipid-lowering medications if significant changes occur. The lipid effects are generally dose-dependent, so using the lowest effective dose of testosterone may help minimize this side effect.
- Key points to consider:
- The study found no significant difference in lipid profiles between men using 50 mg testosterone gel and those using a placebo or other treatments 1.
- Testosterone therapy can affect liver metabolism of lipoproteins, potentially altering cholesterol balance 2.
- Men with pre-existing lipid abnormalities, obesity, or metabolic syndrome may be at higher risk for lipid changes while using testosterone gel 3, 4.
- Regular monitoring of lipid profiles and maintenance of a heart-healthy lifestyle can help minimize potential lipid effects 1, 2.
- It is essential to weigh the benefits and risks of testosterone therapy, considering individual patient factors and medical history, to make informed decisions about treatment.
- The most recent and highest quality study available should guide clinical decision-making, and in this case, the study by 1 provides the most relevant evidence for the use of 50 mg testosterone gel.