What is the best treatment approach for a small gluteal abscess?

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Last updated: June 29, 2025View editorial policy

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From the Guidelines

The best treatment approach for a small gluteal abscess is incision and drainage (I&D), which should be performed as soon as possible. This procedure involves making a small incision over the abscess, evacuating the purulent material, breaking up any loculations, and leaving the wound open to heal by secondary intention. Local anesthesia with 1% lidocaine (avoiding epinephrine) is typically sufficient for small abscesses. After drainage, the wound should be packed lightly with sterile gauze and changed daily until the wound begins to heal.

Key Considerations

  • Antibiotics are generally not required for simple, small abscesses after adequate drainage unless the patient has systemic symptoms (fever, elevated white blood cell count), surrounding cellulitis, immunocompromise, or is at risk for endocarditis.
  • When antibiotics are needed, options include trimethoprim-sulfamethoxazole (one double-strength tablet twice daily), doxycycline (100mg twice daily), or clindamycin (300-450mg four times daily) for 5-7 days to cover MRSA, as recommended by the Infectious Diseases Society of America 1.
  • Warm compresses applied to the area several times daily can help with healing and pain relief.
  • Incision and drainage is the definitive treatment because abscesses represent a walled-off collection of pus that antibiotics alone cannot adequately penetrate, making mechanical drainage necessary for resolution.

Recent Guidelines

Recent guidelines from the World Journal of Emergency Surgery (2018) also support incision and drainage as the primary treatment for skin and soft-tissue infections, including abscesses, with antibiotic therapy reserved for cases with systemic signs of infection, immunocompromised patients, or incomplete source control 1.

From the Research

Treatment Approaches for Small Gluteal Abscess

  • The treatment for a small gluteal abscess can vary depending on the underlying cause and severity of the abscess.
  • In some cases, incision and drainage may be necessary, as seen in a study where a patient with a gluteal abscess due to Crohn's disease underwent surgical incision and drainage, resulting in resolution of pain and fever 2.
  • The use of systemic antibiotics after incision and drainage is still a topic of debate, with some studies suggesting that they may not be necessary for simple abscesses 3.
  • However, in cases where the abscess is caused by a specific infection, such as tuberculosis, antitubercular treatment may be necessary, as seen in a case report of a 3-year-old girl with a gluteal abscess due to Pott's spine 4.

Considerations for Treatment

  • The treatment approach should take into account the location and severity of the abscess, as well as the patient's overall health and medical history.
  • In general, superficial abscesses can be treated with incision and drainage, and antibiotics may not be necessary unless there are signs of systemic infection or the patient is at high risk of complications 5.
  • In the era of increased community-associated methicillin-resistant Staphylococcus aureus (MRSA), it is essential to consider the possibility of MRSA infection when treating abscesses, and to use antibiotics and decolonization strategies judiciously 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Gluteal and Presacral Abscess Due to Crohn's Disease with Multiple Fistulas.

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2022

Research

Abscess incision and drainage in the emergency department--Part I.

The Journal of emergency medicine, 1985

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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