From the Research
The most effective treatment for Tetrahydrocannabinol (THC) syndrome is complete cessation of cannabis use, as symptoms typically resolve within 24-48 hours of abstinence but will recur with continued use. The treatment for THC syndrome primarily involves supportive care and symptom management. For acute management, intravenous fluids should be given to address dehydration, along with antiemetics such as ondansetron 4-8mg IV/PO every 6 hours, metoclopramide 10mg IV/PO every 6 hours, or haloperidol 1-2mg IV/IM every 6 hours (haloperidol has shown particular effectiveness) 1. Topical capsaicin cream (0.075%) applied to the abdomen can also provide relief by activating the same receptors affected during hot showers. Benzodiazepines like lorazepam 1-2mg may help with associated anxiety.
Some key points to consider in the management of THC syndrome include:
- The importance of patient education about the syndrome and its direct relationship to cannabis consumption, as many patients may not initially connect their symptoms to cannabis use 2.
- The potential for increased severity of psychotic symptoms and the risk of acute agitation and aggressive behavior in patients with a history of cannabis use 3, 1.
- The need for careful assessment and management of psychiatric symptoms, including the use of antipsychotic medication and benzodiazepines as needed 4.
- The potential benefits and risks of using cannabis and other cannabinoids for therapeutic purposes, and the need for further research in this area 4.
Overall, the management of THC syndrome requires a comprehensive approach that addresses both the physical and psychiatric symptoms associated with cannabis use, and prioritizes the cessation of cannabis use as the most effective treatment.