Can Ozempic (semaglutide) cause erectile dysfunction (ED)?

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From the Guidelines

Ozempic (semaglutide) is not directly known to cause erectile dysfunction (ED), but it may indirectly affect sexual function through several mechanisms, such as rapid weight loss, nausea, fatigue, and changes in blood sugar levels, which might contribute to reduced sexual desire or performance issues in some individuals. According to the most recent evidence from 1, the common side effects of Ozempic include nausea, vomiting, diarrhea, constipation, headache, fatigue, dyspepsia, dizziness, abdominal distension, eructation, gastroenteritis, and gastroesophageal reflux disease, but erectile dysfunction is not listed as a common side effect. However, it's essential to consider that the medication may affect hormone levels or blood flow, which are important factors in erectile function 1. If you experience ED while taking Ozempic, it's crucial to discuss this with your healthcare provider rather than discontinuing the medication on your own. Your doctor can help determine whether the ED is related to Ozempic or has another cause, and may suggest strategies such as adjusting your dose, addressing other contributing factors like stress or fatigue, or potentially prescribing ED medication if appropriate.

Some key points to consider:

  • Ozempic can cause significant weight loss, which may improve sexual function in the long term for many patients with diabetes 1.
  • The medication may affect hormone levels, which can impact sexual desire and performance 1.
  • Blood flow is an essential factor in erectile function, and Ozempic may have an indirect impact on this aspect 1.
  • It's essential to discuss any concerns or side effects with your healthcare provider to determine the best course of action.

In terms of management, it's crucial to:

  • Monitor your blood sugar levels and adjust your medication as needed 1.
  • Address any contributing factors, such as stress or fatigue, that may be impacting your sexual function.
  • Consider discussing ED medication with your healthcare provider if appropriate.

From the Research

Ozempic and Erectile Dysfunction

  • Ozempic (semaglutide) is a medication used to treat type 2 diabetes and obesity, but there is limited research on its direct effects on erectile dysfunction (ED) 2, 3, 4, 5, 6.
  • However, it is known that certain medications, including those for diabetes and hypertension, can contribute to ED as a side effect 4, 6.
  • The provided studies focus on the treatment of ED using phosphodiesterase type 5 inhibitors, the relationship between ED and cardiovascular disease, and the impact of hypertension and its treatment on ED 2, 3, 4, 5.
  • There is no direct evidence in the provided studies to suggest that Ozempic causes ED, but it is essential to consider the broader context of how medications can influence sexual health 6.

Related Factors

  • Diabetes, a condition often treated with Ozempic, is a known risk factor for ED due to its effects on blood vessels and nerve damage 3, 4.
  • Hypertension, another condition related to the use of Ozempic, can also contribute to ED, and certain antihypertensive medications may exacerbate the condition 4, 6.
  • Lifestyle factors, including regular exercise and a healthy diet, can help mitigate the risk of ED, regardless of medication use 3.

Conclusion Not Applicable

As per the instructions, no conclusion section should be included. The information provided is based on the available evidence and highlights the importance of considering the potential effects of medications on sexual health.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

The treatment of hypertension in patients with erectile dysfunction.

Current medical research and opinion, 2000

Research

Pharmacological aspects of erectile dysfunction.

Japanese journal of pharmacology, 2002

Research

Effect of prescription medications on erectile dysfunction.

Postgraduate medical journal, 2018

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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