From the FDA Drug Label
- 2 Serotonin Syndrome Serotonergic antidepressants, including TRINTELLIX, can precipitate serotonin syndrome, a potentially life-threatening condition. The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, meperidine, methadone, buspirone, amphetamines, and St. John's Wort) and with drugs that impair metabolism of serotonin, i. e., MAOIs [see Contraindications (4), Drug Interactions (7.1)].
You should not take Trintellix and Adderall together due to the increased risk of serotonin syndrome, a potentially life-threatening condition. Amphetamines, such as those found in Adderall, are listed as a class of drugs that can increase this risk when used with serotonergic antidepressants like Trintellix 1.
From the Research
Taking Trintellix (vortioxetine) and Adderall (amphetamine and dextroamphetamine) together should only be done under close medical supervision due to potential drug interactions. These medications can be prescribed together in certain cases, but they carry risks of serotonin syndrome, a potentially serious condition characterized by agitation, hallucinations, rapid heart rate, fever, excessive sweating, shivering, muscle stiffness, twitching, loss of coordination, nausea, vomiting, and diarrhea. The combination works differently in the brain - Trintellix affects serotonin levels to treat depression, while Adderall increases dopamine and norepinephrine to improve focus and attention in ADHD. If you're prescribed both medications, follow your doctor's instructions precisely regarding dosing and timing. Never adjust doses without medical guidance, and report any unusual side effects immediately. Your doctor may start with lower doses of one or both medications and gradually increase them while monitoring for adverse effects. Regular follow-up appointments are essential to assess the effectiveness and safety of this combination for your specific situation, as noted in studies such as 2 which discusses the serotonin syndrome and its implications. Some key points to consider when taking these medications together include:
- Monitoring for signs of serotonin syndrome, as described in 3
- Adjusting doses carefully to minimize risks, as seen in studies like 4 which looked at combining different medications for ADHD and depression
- Regular follow-up with your doctor to assess the effectiveness and safety of the combination, similar to the approach taken in 5 which compared different medications for ADHD. It's crucial to prioritize your safety and well-being when taking any medication, especially when combining them, and to always follow the guidance of a medical professional.