From the Guidelines
For a 57-year-old man, a glutathione dosage of 200-500 mg/day is recommended, particularly in cases of chronic oxidative stress or malabsorption. This recommendation is based on the strongest and most recent evidence from the espen micronutrient guideline published in Clinical Nutrition in 2022 1. The guideline suggests that patients with conditions such as diabetes mellitus, smoking, heart failure, alcoholism, severe COPD, and chronic dialysis may benefit from this dosage range, with a strong consensus of 92% among experts.
Key considerations for glutathione supplementation include:
- Starting with a lower dose and adjusting as needed
- Taking the supplement on an empty stomach to improve absorption
- Consistently taking the supplement for at least 2-3 months to evaluate its effectiveness
- Consulting with a healthcare provider before starting any glutathione regimen, especially if you have existing health conditions or are taking medications
It is essential to note that individual needs and tolerances can vary significantly, and the recommended dosage may need to be adjusted based on specific health conditions or circumstances. The espen micronutrient guideline provides a strong foundation for recommending glutathione supplementation, and healthcare providers can use this guideline to inform their decisions and ensure the best possible outcomes for their patients 1.
From the FDA Drug Label
DOSAGE & ADMINISTRATION Use Morning and evening after bath. The FDA drug label does not answer the question.
From the Research
Glutathione Dosage for a 57-Year-Old Man
The recommended glutathione dosage can vary depending on the specific health goals and conditions. Based on the available studies, here are some key points to consider:
- A study published in 2019 2 found that oral glutathione with a dosage of 500 mg/day could brighten skin color in sun-exposed areas.
- A 2022 study 3 examined the effectiveness of 500 mg oral glutathione supplementation daily for six months in elderly type 2 diabetic patients and found significant improvements in blood GSH levels and HbA1c.
- Another study from 2015 4 investigated the long-term effectiveness of oral GSH supplementation on body stores of GSH in healthy adults and found that GSH levels increased after 1,3, and 6 months versus baseline at both 250 and 1,000 mg/day doses.
- A 2024 study 5 evaluated the effect of reduced L-glutathione supplementation on inflammatory parameters in maintenance hemodialysis patients and used a dosage of 1,000 mg/day for four weeks.
- A 2018 study 6 investigated the effectiveness of oral liposomal GSH administration at two doses (500 and 1,000 mg of GSH per day) and found that GSH levels were elevated after 1 week with maximum increases occurring after 2 weeks.
Key Findings
Some key findings from these studies include:
- Oral glutathione supplementation can increase blood GSH levels and have various health benefits, such as improving skin color, reducing oxidative stress, and enhancing immune function.
- The effective dosage of glutathione can range from 250 to 1,000 mg/day, depending on the specific health goals and conditions.
- Liposomal glutathione administration may be an effective way to elevate GSH levels and impact immune function and oxidative stress.
Dosage Considerations
When considering glutathione supplementation, it's essential to note that:
- The optimal dosage for a 57-year-old man may depend on individual factors, such as overall health, medical conditions, and specific health goals.
- It's crucial to consult with a healthcare professional before starting any supplement regimen, including glutathione, to determine the best course of treatment and dosage.