From the Guidelines
Diosmin should be used to treat hemorrhoids at a dosage of 500-600 mg taken twice daily, with treatment usually lasting 5-7 days for acute episodes and up to 2-3 months for chronic or recurrent cases, as part of a comprehensive management plan that includes dietary and lifestyle changes 1. The treatment of hemorrhoids with diosmin involves not only the administration of the medication but also significant lifestyle adjustments.
- Key aspects of treatment include:
- Dietary changes: increased fiber and water intake to soften stool and reduce strain during bowel movements.
- Lifestyle modifications: adequate bathroom habits, such as not delaying bowel movements and avoiding straining.
- Potential combination with other flavonoids like hesperidin for enhanced effectiveness. Diosmin's mechanism of action, which includes strengthening blood vessel walls, improving venous tone, and reducing inflammation, supports its use in alleviating hemorrhoid symptoms 1. It is crucial for patients to take diosmin with meals to enhance absorption and to stay hydrated throughout the treatment period. Additionally, incorporating sitz baths and topical treatments can provide further relief and support comprehensive hemorrhoid management. While diosmin is generally well-tolerated, with mild side effects such as digestive discomfort, pregnant women should consult their healthcare provider before initiating treatment. The recommendation for diosmin use in hemorrhoid treatment is based on its symptom-relieving properties, as suggested by guidelines for managing complicated hemorrhoids, which include the use of flavonoids like diosmin 1.
From the FDA Drug Label
In general, resolution time of acute flares is shortened from 8 days to 4-5 days. A double-blind, placebo-controlled study (n=120) showed statistically better management of pain, pruritis, discharge, edema, erythema, and bleeding on examination Patients experiencing an acute hemorrhoidal episodes for less then 48 h were enrolled in a randomized, double-blind, placebo-controlled study. One group received diosmin (n=49) and the other a placebo (n=41) During the 7 day administration, there was a significant difference in favor of diosmin in the dietary management of discomfort, edema and bleeding. A study has compared the results of the conservative management of hemorrhoids between diosmin and sclerotherapy (SCL), in terms of the subjective and objective outcome of patients after a follow-up period of 2 years
Diosmin Treatment for Hemorrhoids:
- Duration of Treatment: The duration of treatment is not explicitly stated, but studies have shown significant improvements within 7 days of administration and continued improvement over a 2-year follow-up period.
- Administration: Diosmin can be used to treat hemorrhoids, with studies showing shortened resolution times and improved management of symptoms such as pain, pruritis, discharge, edema, erythema, and bleeding 2.
From the Research
Treatment of Haemorrhoids with Diosmin
Diosmin is used to treat haemorrhoids due to its ability to improve venous tone and lymphatic drainage, and reduce capillary hyperpermeability [(3,4,5)]. The treatment duration and dosage may vary depending on the severity and type of haemorrhoids.
Dosage and Treatment Duration
- For acute internal haemorrhoids, 3 tablets of micronised purified flavonoid fraction (MPFF) 500 mg twice daily for 4 days, then 2 tablets of MPFF 500 mg twice daily for 3 days 3.
- For chronic (recurrent) haemorrhoids, 2 tablets of MPFF 500 mg daily for 60 or 83 days 3.
- In another study, purified diosmin was given at a dose of two 450 mg tablets bid for the first 7 days, then at 1 tablet bid for up to 2 months 5.
Efficacy and Tolerability
Diosmin has been shown to be effective in reducing the frequency, duration, and severity of haemorrhoidal symptoms [(3,4,5)]. It also has a good tolerability profile, with most adverse events being gastrointestinal and autonomic in nature 3.
Additional Considerations
While diosmin can be used as a first-line treatment for haemorrhoids, it may also be used in conjunction with other treatments such as sclerotherapy, surgery, and/or compression therapy 3.