From the Research
Aesthetic fillers, such as hyaluronic acid (HA) fillers like Juvederm and Restylane, do eventually fully dissolve in the body, with the dissolution rate dependent on the type of filler, individual metabolism, and injection location. The body naturally breaks down hyaluronic acid over time using an enzyme called hyaluronidase, which gradually metabolizes the filler material 1. Different formulations have different longevity, with thicker, more cross-linked products like Juvederm Voluma or Restylane Lyft (used for cheek augmentation) tend to last longer (up to 18-24 months), while thinner formulations used for lips or fine lines may dissolve within 6-12 months 2.
Some key points to consider:
- The efficacy of hyaluronidase in dissolving HA fillers varies based on the type of filler and the enzyme's concentration 1.
- Biphasic fillers dissolve more rapidly at lower concentrations of hyaluronidase compared to monophasic fillers, which require higher concentrations and longer exposure times for effective breakdown 1.
- Direct injection of hyaluronidase into the filler mass is more effective than surface application 1.
- If faster dissolution is desired, a medical professional can inject hyaluronidase to rapidly break down the filler within 24-48 hours 3.
Overall, the reversibility of HA fillers is one of the main safety advantages compared to permanent fillers, and the gradual dissolution process explains why patients need maintenance treatments to sustain their desired aesthetic results 4. The use of hyaluronidase is a effective way to dissolve HA fillers, and its efficacy depends on the type of filler, concentration, and application technique 1.