What is the treatment for folliculitis on the scrotum?

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Last updated: June 30, 2025View editorial policy

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From the Guidelines

Folliculitis on the scrotum should be treated with a combination of good hygiene practices and medications, starting with gentle cleansing and topical antibiotics for mild cases, and progressing to oral antibiotics for more severe or persistent cases, as recommended by the most recent guidelines 1. The treatment approach for folliculitis on the scrotum depends on the severity of the condition. For mild cases, gentle cleansing of the area twice daily using antibacterial soap, followed by thorough drying, is a good starting point. Over-the-counter options include applying 2.5% benzoyl peroxide wash or cream once daily, though this should be used carefully due to potential skin irritation. Some key points to consider in the treatment of folliculitis include:

  • For more persistent cases, topical antibiotics like clindamycin 1% or mupirocin 2% applied twice daily for 7-10 days are effective 1.
  • If the condition doesn't improve or is severe, oral antibiotics such as cephalexin (500mg four times daily), doxycycline (100mg twice daily), or trimethoprim-sulfamethoxazole (one double-strength tablet twice daily) for 7-10 days may be prescribed.
  • Warm compresses applied to the area for 15 minutes several times daily can help reduce inflammation and promote healing.
  • To prevent recurrence, wear loose-fitting cotton underwear, avoid sharing personal items, change clothes after sweating, and maintain good hygiene. It's also important to note that folliculitis occurs when hair follicles become infected, typically by Staphylococcus bacteria, with the warm, moist environment of the scrotum making it particularly susceptible. The 2018 WSES/SIS-E consensus conference recommendations for the management of skin and soft-tissue infections provide a useful framework for classifying and treating SSTIs, including folliculitis 1.

From the Research

Treatment for Folliculitis on the Scrotum

The treatment for folliculitis on the scrotum typically involves addressing the bacterial infection and reducing inflammation. Some key points to consider:

  • Folliculitis can be caused by bacterial, fungal, or viral infections, and treatment should be tailored to the underlying cause 2.
  • Topical and oral antibiotics are commonly used to treat folliculitis, with the goal of stopping inflammation and preventing further destruction of hair follicles 3.
  • Specific treatments that have shown promise for folliculitis include:
    • Fusidic acid, which has been used successfully in some cases of folliculitis decalvans 3.
    • Turpentine ointment, which has been shown to be effective in reducing follicle lesion counts and improving symptoms 4.
    • Oral isotretinoin, which has been found to be a highly effective treatment for folliculitis decalvans, with a high success rate in achieving long-term remission 5.
  • Other treatment options that have been used for folliculitis include radiation therapy 6 and combination therapies such as clindamycin and rifampicin 5.
  • It's essential to note that the treatment of folliculitis should be individualized, and the choice of treatment will depend on the severity and underlying cause of the condition, as well as the patient's overall health and medical history 2, 3, 4, 6, 5.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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