From the FDA Drug Label
- 7 Cognitive/Neuropsychiatric Adverse Reactions Use of oxcarbazepine has been associated with central nervous system-related adverse reactions The most significant of these can be classified into 3 general categories:
- cognitive symptoms including psychomotor slowing, difficulty with concentration, and speech or language problems,
- somnolence or fatigue, and
- coordination abnormalities, including ataxia and gait disturbances
In one large, fixed-dose study, ... 7. 1% of oxcarbazepine-treated patients and 4% of placebo-treated patients experienced a cognitive adverse reaction.
Cognitive adverse events occurred in 5.8% of oxcarbazepine-treated patients (the single most common event being concentration impairment, 4 of 138 patients)
Yes, Trileptal (oxcarbazepine) can cause memory problems, including difficulty with concentration and cognitive impairment 1.
From the Research
Trileptal (oxcarbazepine) is not typically associated with causing significant memory problems as a side effect, according to the most recent and highest quality studies available. Memory issues are considered cognitive side effects of anticonvulsant medications, but oxcarbazepine has been shown to have a relatively favorable cognitive profile compared to other antiepileptic drugs. The risk of cognitive side effects appears to be low, and oxcarbazepine may even have mild improvements on attentional tests, as suggested by studies such as 2.
Some studies have compared the cognitive effects of oxcarbazepine with other antiepileptic drugs, and the results indicate that oxcarbazepine does not have a significant negative impact on cognitive function. For example, a study published in the Journal of Clinical Neurology found that low-dose topiramate had a negative effect on working memory and verbal fluency compared to oxcarbazepine, suggesting that oxcarbazepine may be a better option for patients concerned about cognitive side effects 3.
It's essential to note that individual responses to medications can vary, and some patients may still experience cognitive side effects while taking oxcarbazepine. However, based on the available evidence, oxcarbazepine is generally considered to be a safe and effective treatment option with a low risk of significant memory problems. If you're taking Trileptal and experiencing memory problems, it's crucial to discuss this with your healthcare provider rather than stopping the medication abruptly, as they can help determine the best course of action and adjust your treatment plan as needed.