What is the role of alcohol sclerosing (AS) injections in the treatment of Morton's neuroma?

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Last updated: June 30, 2025View editorial policy

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From the Research

Alcohol sclerosing injections are a viable treatment option for Morton's neuroma, with a success rate of over 82% per single injection, as demonstrated in the most recent and highest quality study 1. The procedure involves injecting a solution of 70% ethanol, as shown to be effective in the study 1, mixed with a local anesthetic directly into the affected intermetatarsal space. Some key points to consider when using alcohol sclerosing injections for Morton's neuroma include:

  • The use of fluoroscopic and electroneurographic guidance to ensure accurate placement of the injection, as described in the study 1
  • The potential for significant improvement in pain scores, with a "success rate" of more than 82% per single injection, as reported in the study 1
  • The possibility of mild pain persisting in some patients who participate in sports, as noted in the study 1
  • The importance of using a higher percentage of ethanol, such as 70%, and a higher dosage, such as 2.5 mL, as shown to be effective in the study 1 It is also important to consider the findings of other studies, such as the one published in 2020 2, which reported a success rate of 71.2% with percutaneous alcoholization of Morton's neuroma with phenol by electrostimulation guidance. However, the most recent and highest quality study 1 provides the strongest evidence for the effectiveness of alcohol sclerosing injections in treating Morton's neuroma. Overall, alcohol sclerosing injections can be a safe and effective treatment option for Morton's neuroma, with a high success rate and minimal side effects, as demonstrated in the study 1.

References

Research

Can percutaneous alcoholization of Morton's neuroma with phenol by electrostimulation guidance be an alternative to surgical excision? Long-term results.

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons, 2020

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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