Can Lamictal (lamotrigine) cause erectile dysfunction?

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From the Research

Lamictal (lamotrigine) can cause erectile dysfunction, although it is considered to have a lower risk of sexual side effects compared to other psychiatric medications. According to a study published in 2016 1, sexual dysfunction related to antiepileptic drugs, including lamotrigine, is common, and symptoms can include erectile dysfunction. The study found that lamotrigine may improve sexual function, but it can also cause sexual dysfunction in some cases.

The exact mechanism of how lamotrigine affects sexual function is not fully understood, but it is thought to be related to its effects on sodium channels and the release of excitatory neurotransmitters in the brain 1. If you experience erectile dysfunction while taking Lamictal, it is essential to discuss this with your healthcare provider rather than discontinuing the medication on your own. Your doctor may consider adjusting your dosage, changing the timing of when you take the medication, or possibly prescribing additional treatments to address the erectile dysfunction.

Some key points to consider:

  • Sexual dysfunction, including erectile dysfunction, is reported in approximately 1-5% of patients taking lamotrigine.
  • Lamotrigine may improve sexual function in some cases, but it can also cause sexual dysfunction.
  • The treatment for sexual dysfunction related to lamotrigine is not well established, but switching to an alternative medication with a lower risk of sexual side effects may be an option.
  • It is crucial to discuss any sexual side effects with your healthcare provider to determine the best course of action.

In terms of managing erectile dysfunction, there are several treatment options available, including phosphodiesterase-5 inhibitors such as sildenafil, tadalafil, and vardenafil 2, 3. However, these medications may interact with other medications, including lamotrigine, and should be used with caution. It is essential to consult with your healthcare provider before starting any new medication, especially if you are already taking lamotrigine.

References

3
Research

The use of phosphodiesterase 5 inhibitors with concomitant medications.

Journal of endocrinological investigation, 2008

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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