Differential Diagnosis for Burning Sensation with Ejaculation

• Single most likely diagnosis
  • Prostatitis: This condition, which involves inflammation of the prostate gland, is a common cause of painful ejaculation. The burning sensation can be due to the inflammation and irritation of the prostate and surrounding tissues.
• Other Likely diagnoses
  • Urethritis: Inflammation of the urethra can cause a burning sensation during ejaculation due to the irritation of the urethral lining.
  • Epididymitis: Inflammation of the epididymis, a tube at the back of the testicle that stores and carries sperm, can cause pain and discomfort during ejaculation.
  • Seminal vesiculitis: Inflammation of the seminal vesicles, which are glands that produce a significant portion of the fluid in semen, can cause painful ejaculation.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Testicular cancer: Although rare, testicular cancer can cause pain or discomfort in the testicles, which might radiate to the area involved in ejaculation, leading to a burning sensation.
  • Gonorrhea or Chlamydia: These sexually transmitted infections (STIs) can cause urethritis and epididymitis, leading to painful ejaculation. Missing these diagnoses can lead to serious complications, including infertility and increased risk of spreading the infection.
• Rare diagnoses
  • Interstitial cystitis: A chronic condition causing bladder pressure, bladder pain, and sometimes pelvic pain, which might be perceived as a burning sensation during ejaculation.
  • Sjögren's syndrome: An autoimmune disorder that can cause dryness in various parts of the body, including the genital area, potentially leading to discomfort or a burning sensation during ejaculation.
  • Neurological disorders: Certain conditions affecting the nerves, such as multiple sclerosis or peripheral neuropathy, can cause abnormal sensations, including burning, during ejaculation.