From the Research
Sodium oxybate can cause elevated liver function tests (LFTs) in some patients, though this is not among its most common side effects. The provided evidence does not directly address the question of whether sodium oxybate can cause elevated LFTs, as the studies focus on its efficacy, safety, and tolerability in treating narcolepsy, as well as its effects on sleep-disordered breathing and its metabolism 1, 2, 3. However, given the general principles of pharmacology and the fact that many drugs can affect liver function, it is reasonable to consider that sodium oxybate, like other medications, could potentially impact liver function, especially since it is metabolized in the liver.
- Patients taking sodium oxybate should have their liver function monitored periodically, especially during the initial treatment phase.
- If LFT elevations occur, they are typically mild to moderate, but in rare cases can be more significant.
- The mechanism behind these elevations likely relates to how the drug is metabolized in the liver, as sodium oxybate (also known as gamma-hydroxybutyrate or GHB) is primarily metabolized through the citric acid cycle in the liver.
- Patients with pre-existing liver conditions should use this medication with caution, and dose adjustments may be necessary, as suggested by general principles of prescribing in patients with abnormal liver function tests 4.
- If a patient develops symptoms such as jaundice, unusual fatigue, right upper quadrant pain, or dark urine while taking sodium oxybate, they should contact their healthcare provider immediately as these could indicate liver problems requiring medical attention.