From the Research
DAO (Diamine Oxidase) supplementation is a recommended approach to manage histamine levels, particularly for individuals with histamine intolerance or insufficient natural DAO production, as it provides additional enzymes to break down histamine in the digestive tract. For those with histamine intolerance, taking DAO supplements about 15-30 minutes before meals containing histamine can help prevent or reduce symptoms like headaches, digestive issues, skin reactions, and nasal congestion 1. Typical supplementation involves 1-2 capsules (usually containing 10,000-20,000 HDU of DAO) before meals that might contain histamine-rich foods such as aged cheeses, fermented foods, alcohol, or processed meats. DAO supplements work locally in the intestines where they intercept dietary histamine before it can be absorbed into the bloodstream. This supplementation approach is particularly helpful for those with confirmed histamine intolerance, DAO enzyme deficiency, or those experiencing histamine-related symptoms after consuming high-histamine foods. However, DAO supplements don't address histamine produced within the body and are not a cure for underlying conditions causing histamine intolerance. They should be used as part of a comprehensive approach that may include dietary modifications and addressing root causes of histamine sensitivity.
Some key points to consider when using DAO supplements include:
- The importance of taking DAO supplements before meals that may contain histamine-rich foods to maximize their effectiveness
- The need for individualized dosing, as the optimal amount of DAO supplementation may vary from person to person
- The potential for DAO supplements to be used in conjunction with other therapies, such as antihistamines or dietary modifications, to manage histamine intolerance
- The importance of consulting with a healthcare professional before starting DAO supplementation, particularly for individuals with underlying medical conditions or taking medications that may interact with DAO supplements.
It's also worth noting that while DAO supplements can be beneficial for managing histamine levels, they may not be effective for everyone, and more research is needed to fully understand their effects and optimal dosing strategies 2, 3, 4, 5.