Differential Diagnosis for Pain on the Lateral Aspect of the Foot
Single Most Likely Diagnosis
- Peroneal Tendinopathy: This condition is characterized by inflammation or degeneration of the peroneal tendons, which run along the lateral aspect of the foot and ankle. It is a common cause of lateral foot pain, especially in individuals who participate in activities that involve repetitive ankle motion.
Other Likely Diagnoses
- Cuboid Syndrome: This condition involves inflammation of the cuboid bone or the surrounding soft tissues on the lateral aspect of the foot. It can cause pain and is often associated with activities that involve inversion of the foot.
- Lateral Plantar Fasciitis: While plantar fasciitis more commonly affects the medial aspect of the heel, it can also occur on the lateral side, causing pain on the lateral aspect of the foot.
- Stress Fracture of the Fifth Metatarsal: A stress fracture in this bone, which is located on the lateral aspect of the foot, can cause pain in this area, especially with weight-bearing activities.
Do Not Miss Diagnoses
- Compartment Syndrome: Although less common, compartment syndrome is a serious condition that requires prompt diagnosis and treatment. It involves increased pressure within the compartments of the foot, which can lead to nerve and muscle damage.
- Deep Vein Thrombosis (DVT): While DVTs are more commonly associated with the calf, they can occur in the foot and cause pain. Given the potential for serious complications like pulmonary embolism, DVT should not be missed.
- Osteomyelitis or Septic Arthritis: Infections of the bone or joint can cause severe pain and have significant consequences if not treated promptly.
Rare Diagnoses
- Tarsal Coalition: An abnormal connection between two or more of the tarsal bones in the foot can cause pain on the lateral aspect, especially if it involves the calcaneocuboid joint.
- Erythromelalgia: A rare disorder characterized by burning pain, heat, and redness in the feet, which can sometimes be localized to the lateral aspect.
- Neuroma of the Foot: Although more commonly found between the third and fourth toes (Morton's neuroma), a neuroma can theoretically occur on the lateral aspect of the foot, causing pain.