From the Research
Yes, Janumet (sitagliptin and metformin) can potentially cause blurry vision in some patients, particularly due to the metformin component when blood sugar levels are changing rapidly. This side effect is associated with the fluctuating blood sugar levels affecting the fluid balance in the eye's lens, temporarily changing its shape and affecting focus 1.
Key Points to Consider
- Blurry vision may occur when starting the medication or when adjusting the dosage as the body adapts to new blood glucose levels.
- The sitagliptin component of Janumet has been studied for its potential in treating diabetic retinopathy, suggesting its role in ocular health, but its direct impact on vision when used orally in combination with metformin is less clear 1.
- If persistent blurry vision is experienced while taking Janumet, it is crucial to contact a healthcare provider promptly, as it could also be a symptom of other diabetes-related eye complications.
- Regular eye examinations are recommended for people with diabetes, regardless of medication adjustments, due to the increased risk of serious eye conditions like diabetic retinopathy.
Pharmacokinetics and Distribution
The pharmacokinetics of sitagliptin, when administered as eye drops, indicate that it reaches the retina prior to the aqueous and vitreous humors, suggesting absorption via the transscleral route, with minimal systemic absorption 1. However, this information is specific to the use of sitagliptin in eye drop form and may not directly apply to its use in oral form as part of Janumet.
Clinical Implications
Given the potential for blurry vision and the importance of monitoring eye health in diabetic patients, it is essential for patients taking Janumet to be aware of these risks and to maintain regular follow-up appointments with their healthcare provider. While the provided studies do not directly address the incidence of blurry vision as a side effect of Janumet, they highlight the importance of considering ocular health in the management of diabetes 2, 1.