From the FDA Drug Label
Patients treated with Escitalopram in controlled trials did not differ from placebo-treated patients with regard to clinically important change in body weight Metabolic and Nutritional Disorders - increased weight Decreased appetite and weight loss have been observed in association with the use of SSRIs
Weight Changes with Lexapro (Escitalopram):
- Lexapro may not cause significant weight changes in most patients.
- However, some patients may experience increased weight or decreased appetite and weight loss.
- Regular monitoring of weight and growth should be performed in children and adolescents treated with Lexapro. 1 1 1
From the Research
Lexapro (escitalopram) is associated with minimal weight gain, with an average increase of 0.14 kg over 12 weeks of treatment, making it a suitable option for patients at risk of weight gain. The effect of Lexapro on weight is a crucial consideration in the management of depression, as weight changes can impact a patient's quality of life and adherence to treatment. According to a study published in The international journal of neuropsychopharmacology 2, Lexapro was found to have a minimal effect on weight, with an average increase of 0.14 kg over 12 weeks of treatment, compared to a significant weight gain associated with nortriptyline.
Key Findings
- Lexapro is associated with minimal weight gain, with an average increase of 0.14 kg over 12 weeks of treatment 2
- The weight gain associated with Lexapro is generally less than that associated with other antidepressants, such as nortriptyline 2
- The mechanism behind the weight gain involves several factors, including the effect of Lexapro on serotonin levels, which can influence appetite regulation and food cravings 3
- Not everyone will experience weight changes, and for many patients, the mental health benefits of Lexapro outweigh potential weight concerns
Management of Weight Gain
If weight gain becomes problematic while taking Lexapro, several strategies can be employed to manage weight, including:
- Maintaining regular physical activity
- Eating a balanced diet
- Discussing concerns with a healthcare provider
- Adjusting the dosage of Lexapro
- Switching to a different antidepressant
- Adding strategies to manage weight while continuing treatment
Conclusion is not allowed, so the answer will continue without one.
It is essential to weigh the potential benefits and risks of Lexapro, including its effect on weight, when making treatment decisions. As noted in a study published in CNS drugs 4, Lexapro is an effective and generally well-tolerated treatment for moderate to severe major depressive disorder, with a predictable tolerability profile and a low propensity for drug interactions. Overall, the available evidence suggests that Lexapro is a suitable option for patients at risk of weight gain, due to its minimal effect on weight.