There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
The FDA Drug Labels for leuprolide (IM) do not address this question.
From the Research
Effects of Lupron (Leuprolide) on Weight
- The study 1 found that leuprolide acetate causes more weight gain in obese people and increases the risk of obesity-related diseases among these patients.
- This study suggests that treatment with leuprolide acetate should be used with caution in obese patients with endometriosis.
- Another study 2 mentions that one of the possible side effects of leuprolide acetate treatment is an increase in BMI, which is a concern for some patients.
- However, the study 3 does not mention weight gain as a side effect of leuprolide acetate treatment in children with central precocious puberty.
- The studies 4 and 5 do not provide information on the effects of leuprolide acetate on weight gain.
Side Effects of Lupron (Leuprolide)
- Common side effects of leuprolide acetate treatment include hypoestrogenism, such as cramps and spotting, as well as endogenous complications like oily skin, acne, and hirsutism 1.
- The study 2 mentions that leuprolide acetate can cause a reduction in bone mineral density, which is a concern for long-term treatment.
- The study 4 found that leuprolide treatment affects the development of reproductive physiology and behavior in female and male rats differently, but both mature after treatment termination.
Clinical Applications of Leuprolide Acetate
- Leuprolide acetate is used to treat a wide range of sex hormone-related disorders, including advanced prostatic cancer, endometriosis, and precocious puberty 2.
- It is also used as an adjuvant therapy in women undergoing in vitro fertilization or gamete intrafallopian transfer 2.
- The study 5 mentions that leuprolide acetate is being tested for the treatment of various diseases, including Alzheimer's disease, polycystic ovary syndrome, and functional bowel disease.