From the Research
Alpha-lipoic acid (ALA) can cause severe side effects, including multi-organ failure and death, especially at high doses, as reported in a recent case study 1. The side effects of ALA can be categorized into common and rare effects. Common side effects include:
- Nausea
- Vomiting
- Diarrhea
- Skin rash
- Burning sensation in the mouth Some people may experience:
- Headaches
- Dizziness
- Metallic taste in the mouth At higher doses, ALA may lower blood sugar levels, which can be problematic for diabetics taking glucose-lowering medications. It may also cause allergic skin reactions in some individuals. ALA can potentially interact with certain medications, including chemotherapy drugs, thyroid medications, and insulin. In rare cases, it may affect thyroid function or cause hypoglycemia, as seen in cases of insulin autoimmune syndrome induced by ALA 2. Pregnant or breastfeeding women should avoid ALA due to insufficient safety data. The typical recommended dosage ranges from 300-600 mg daily for general antioxidant support, though therapeutic doses for specific conditions may vary. If you experience severe side effects or allergic reactions while taking ALA, discontinue use and consult a healthcare provider immediately. It is essential to be aware of the potential toxicity of ALA, as reported in recent studies 1, 3, and to monitor patients for signs of adverse reactions, especially when taking high doses.