From the Research
A Mean Corpuscular Hemoglobin Concentration (MCHC) of 31.2 g/dL is slightly below the normal reference range, indicating mild hypochromia, and according to the most recent study 1, it is crucial to first rule out any interfering factors that could cause false elevation or depression of MCHC levels. This finding suggests that the red blood cells contain less hemoglobin than normal. No immediate intervention is required for this isolated mild decrease, but further investigation is warranted to determine the underlying cause. The most common causes include:
- Iron deficiency anemia
- Thalassemia trait
- Anemia of chronic disease Management should include:
- A complete blood count with peripheral smear review
- Iron studies (serum iron, ferritin, total iron binding capacity)
- Possibly hemoglobin electrophoresis if thalassemia is suspected If iron deficiency is confirmed, oral iron supplementation (such as ferrous sulfate 325 mg daily or twice daily) would be recommended, taken with vitamin C to enhance absorption and between meals to minimize gastrointestinal side effects, as supported by a study on the effects of oral iron supplementation 2. Treatment duration typically ranges from 3-6 months to replenish iron stores. The slightly decreased MCHC reflects reduced hemoglobin synthesis relative to red cell volume, which affects oxygen-carrying capacity and may cause symptoms like fatigue if hemoglobin levels are significantly reduced, highlighting the importance of addressing the underlying cause, as emphasized in a study on the prognostic impact of relative hypochromia in acute heart failure 3.