From the Research
Discontinuing atomoxetine (Strattera) for 3 days is unlikely to have a significant negative effect, as studies have shown that atomoxetine discontinuation does not result in symptom rebound or discontinuation-emergent adverse effects. According to a study published in the Journal of Clinical Psychopharmacology 1, the incidence of discontinuation-emergent adverse events was low, and there were no statistically significant differences between patients abruptly discontinuing from atomoxetine and those continuing on placebo.
When considering the potential effects of stopping atomoxetine, it's essential to understand the medication's pharmacokinetics. Atomoxetine has a half-life of about 5-24 hours, so stopping for 3 days means the medication will largely clear from your system, potentially causing a return of ADHD symptoms like difficulty concentrating, impulsivity, and hyperactivity. Some people may also experience withdrawal effects, including irritability, mood swings, fatigue, or headaches. The severity of these effects varies based on your dosage (typically 40-100mg daily for adults), how long you've been taking the medication, and individual factors.
Key points to consider:
- Atomoxetine can be discontinued without risk for symptom rebound or discontinuation-emergent adverse effects 1
- The medication's half-life is about 5-24 hours, so stopping for 3 days will largely clear it from your system
- Withdrawal effects, such as irritability or fatigue, may occur but are generally mild
- If you need to stop temporarily, it's best to consult your healthcare provider first
- When restarting after a brief break, you may not need to titrate up from a lower dose, but this should be confirmed with your doctor 1
It's also important to note that repeatedly stopping and starting atomoxetine can reduce the medication's overall effectiveness in managing ADHD symptoms. Therefore, if you need to stop taking atomoxetine, it's crucial to discuss this with your healthcare provider to determine the best course of action.