What are the treatment options for Temporomandibular Joint (TMJ) disorders?

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Last updated: July 1, 2025View editorial policy

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From the Guidelines

Treatment for Temporomandibular Joint (TMJ) disorders should begin with conservative, non-surgical approaches, prioritizing self-care measures, over-the-counter pain medications, and physical therapy, before considering more invasive interventions, as recommended by the most recent guidelines 1. The initial treatment approach for TMJ disorders typically includes:

  • Self-care measures such as eating soft foods, avoiding extreme jaw movements, applying ice or heat packs, and practicing gentle jaw stretching exercises
  • Over-the-counter pain medications like ibuprofen (400-800mg three times daily) or naproxen (500mg twice daily) to manage pain and inflammation
  • Physical therapy focusing on jaw exercises and proper posture to improve joint mobility and reduce muscle tension
  • Occlusal splints or night guards custom-fitted by dentists to prevent teeth grinding and reduce muscle tension If these conservative measures are insufficient, healthcare providers may prescribe:
  • Muscle relaxants such as cyclobenzaprine (5-10mg at bedtime) for short-term use
  • Tricyclic antidepressants like amitriptyline (10-25mg at bedtime) for chronic pain
  • Cognitive behavioral therapy to address stress-related factors contributing to TMJ disorders Surgical options, including arthrocentesis, arthroscopy, or open-joint surgery, are reserved for severe cases that don't respond to conservative treatments, as recommended by recent guidelines 1. It's essential to note that the treatment approach may vary depending on the underlying cause of the TMJ disorder, which can include inflammation, muscle tension, joint misalignment, or a combination of these factors, and healthcare providers should consider the most recent guidelines and individual patient needs when developing a treatment plan 1.

From the Research

Treatment Options for Temporomandibular Joint (TMJ) Disorders

The treatment options for TMJ disorders include:

  • Noninvasive pharmacologic therapies, such as nonsteroidal anti-inflammatory drugs, muscle relaxants, benzodiazepines, antidepressants, and anticonvulsants 2
  • Minimally invasive muscular and articular injections, including botulinum toxin, corticosteroids, platelet-rich plasma, hyaluronic acid, and prolotherapy with hypertonic glucose 2
  • Surgery, which may be considered for severe cases of TMJ disorder

Pharmacological Agents for TMJ Disorders

Pharmacological agents commonly used for the treatment of TMJ disorders include:

  • Non-steroidal anti-inflammatory drugs (NSAIDs) 3
  • Opioids 3
  • Corticosteroids 3, 4
  • Muscle relaxants 3
  • Antidepressants 3
  • Anticonvulsants 3
  • Benzodiazepines 3
  • Glucosamine sulfate, which has been shown to be effective in reducing pain and improving mandibular opening in patients with TMJ osteoarthritis 4, 5

Non-Pharmacological Interventions for TMJ Disorders

Non-pharmacological interventions for TMJ disorders include:

  • Occlusal splints, which have been shown to be effective in reducing pain and improving function in patients with TMJ disorders 6
  • Physical therapy, which may include exercises to improve jaw mobility and reduce pain
  • Self-care, such as avoiding chewing gum and eating soft foods

Comparison of Treatment Options

Studies have compared the effectiveness of different treatment options for TMJ disorders, including:

  • A study that found glucosamine sulfate to be more effective and safer than ibuprofen in reducing pain and improving mandibular opening in patients with TMJ osteoarthritis 5
  • A study that found intra-articular injections of sodium hyaluronate or corticosteroid preparations to be effective in reducing pain and improving function in patients with TMJ osteoarthritis 4

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Pharmacologic Treatment for Temporomandibular and Temporomandibular Joint Disorders.

Oral and maxillofacial surgery clinics of North America, 2022

Research

Pharmacotherapy in Temporomandibular Disorders: A Review.

Journal (Canadian Dental Association), 2017

Research

Interventions for the management of temporomandibular joint osteoarthritis.

The Cochrane database of systematic reviews, 2012

Research

Effect of occlusal splints on TMJ symptomatology.

The Journal of prosthetic dentistry, 1978

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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