From the Research
Topical heparin is not routinely recommended for wound care or skin ulcers in standard clinical practice. While heparin has anti-inflammatory, anti-coagulant, and angiogenic properties that theoretically could benefit wound healing, there is insufficient high-quality evidence supporting its topical use for wounds 1. When used experimentally, concentrations have ranged from 1,000 to 5,000 IU/g in various formulations including gels, creams, or solutions, typically applied once or twice daily with dressing changes.
Key Considerations
- Application involves cleaning the wound, applying a thin layer of the heparin preparation directly to the wound bed, and covering with an appropriate dressing.
- Treatment duration varies based on wound healing progress.
- Potential benefits may include reduced inflammation, improved microcirculation, and enhanced tissue regeneration.
- However, clinicians should be aware of possible side effects including local irritation, delayed clotting at the wound site, and allergic reactions.
Prioritizing Evidence-Based Wound Care
Most importantly, standard evidence-based wound care approaches should be prioritized, including:
- Appropriate debridement
- Infection control
- Moisture balance
- Addressing underlying causes of poor healing such as pressure offloading, vascular insufficiency, or metabolic disorders 2.
Given the most recent and highest quality study available 1, the focus should remain on established wound care practices rather than topical heparin for wound care or skin ulcers.