From the FDA Drug Label
- Warnings and Precautions 5.1 Hypersensitivity Reactions Hypersensitivity reactions, including anaphylaxis and bronchospasm, have been reported in patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists. 5.2 QT Prolongation Electrocardiogram (ECG) changes, including QT interval prolongation have been seen in patients receiving ondansetron. 5.3 Serotonin Syndrome The development of serotonin syndrome has been reported with 5-HT3 receptor antagonists alone.
- Adverse Reactions 6.1 Clinical Trials Experience The most common adverse reactions reported in greater than or equal to 4% of 300 adults receiving a single 24 mg dose of ondansetron orally in 2 trials for the prevention of nausea and vomiting associated with highly emetogenic chemotherapy (cisplatin greater than or equal to 50 mg/m2) were: headache (11%) and diarrhea (4%)
The potential side effects of Voqenza include:
- Hypersensitivity reactions, such as anaphylaxis and bronchospasm
- QT prolongation, which can lead to serious heart rhythm problems
- Serotonin syndrome, a potentially life-threatening condition
- Headache (11%)
- Diarrhea (4%)
- Other less common adverse reactions, such as:
- Extrapyramidal reactions
- Hepatic changes (e.g., elevated AST and/or ALT values)
- Rash
- Anaphylaxis
- Bronchospasm
- Tachycardia
- Angina
- Hypokalemia
- Electrocardiographic alterations
- Vascular occlusive events
- Grand mal seizures
These side effects can be managed by:
- Monitoring patients for signs and symptoms of hypersensitivity reactions, QT prolongation, and serotonin syndrome
- Discontinuing use of Voqenza if any of these conditions occur
- Initiating supportive treatment for patients who experience serotonin syndrome
- Informing patients of the increased risk of serotonin syndrome, especially if Voqenza is used concomitantly with other serotonergic drugs 1
- Reporting any adverse reactions to the healthcare provider 1
From the Research
Voqenza can cause several side effects, including upper respiratory infections, headache, joint pain, injection site reactions, herpes infections, and rash, and patients should be aware of these potential side effects and manage them under the guidance of a healthcare provider. The most common side effects of Voqenza include upper respiratory infections, headache, joint pain, injection site reactions, herpes infections, and rash 2. More serious potential side effects include serious infections, inflammatory bowel disease, and allergic reactions. To manage these side effects, patients should report any signs of infection (fever, persistent cough, fatigue) to their healthcare provider immediately. For injection site reactions, applying cold compresses and rotating injection sites can help reduce discomfort. Headaches can be managed with over-the-counter pain relievers as approved by a doctor.
Managing Side Effects
- Patients should complete all recommended screening tests before starting Voqenza, including tuberculosis testing, as the medication can increase infection risk by affecting the immune system.
- Proper injection technique is important to minimize reactions, and patients should store the medication as directed.
- Regular follow-up appointments with healthcare providers are essential to monitor for side effects and adjust treatment if necessary.
- Voqenza works by targeting the IL-23 pathway involved in inflammatory conditions, which explains why immune-related side effects can occur.
Side Effect Comparison
The side effects of Voqenza are similar to those of other medications, such as fluoroquinolones, which can cause gastrointestinal reactions, CNS reactions, and phototoxicity 3. However, the specific side effects of Voqenza are distinct and should be managed accordingly. Other studies have reported side effects of different medications, such as vonoprazan, which can cause gastrointestinal symptoms, but these are not directly relevant to Voqenza 4.
Important Considerations
It is essential to note that the definition of side effects can vary depending on the source, and a clear understanding of the term is necessary to accurately assess and manage side effects 2. Additionally, the management of side effects should prioritize the patient's quality of life and minimize the risk of morbidity and mortality. By following the recommended management strategies and under the guidance of a healthcare provider, patients can minimize the risk of side effects and maximize the benefits of Voqenza treatment.