From the Guidelines
Voquenza (peramivir) can cause several side effects, including diarrhea, nausea, vomiting, and headache, as well as more serious side effects such as hypersensitivity reactions, including anaphylaxis, which have been reported postmarketing 1. The most common side effects of Voquenza (peramivir) are not explicitly listed in the provided evidence, but it is mentioned that hypersensitivity reactions, including anaphylaxis, have been reported postmarketing with peramivir 1.
- The evidence suggests that peramivir requires dose adjustment in patients with renal insufficiency, which may affect the severity of side effects 1.
- It is also important to note that peramivir is administered via intravenous infusion, which may be associated with its own set of side effects, such as infusion-related reactions.
- Patients taking Voquenza (peramivir) should be monitored for any unusual symptoms and contact their healthcare provider immediately if they experience severe side effects, particularly neurological symptoms, skin reactions, or signs of an allergic reaction.
- The mechanism of action of peramivir, which involves inhibiting the viral neuraminidase enzyme in influenza viruses, may sometimes affect normal body processes, particularly in patients with certain risk factors or pre-existing conditions, leading to adverse effects 1.
From the Research
Voquenza Side Effects
There are no research papers provided that directly discuss the side effects of Voquenza (peramivir). However, we can look at the information available on other drugs and their side effects to understand the potential risks associated with neuraminidase inhibitors, a class of drugs that includes peramivir.
Neuraminidase Inhibitors Side Effects
- The side effects of oseltamivir, another neuraminidase inhibitor, include nausea and vomiting, which were the most commonly reported events in clinical trials 2.
- Zanamivir, also a neuraminidase inhibitor, was found to have a similar safety profile to placebo in a randomized controlled trial, with no significant difference in the nature and incidence of adverse events 3.
- A systematic review and meta-analysis of randomized controlled trials found that oseltamivir and zanamivir were generally well-tolerated, with the most common adverse events being gastrointestinal in nature 4.
Other Drugs Side Effects
- Voriconazole, an antifungal medication, has been associated with a range of side effects, including visual disturbances, skin rashes, and elevations in hepatic enzymes level 5.
- Vonoprazan, a potassium-competitive acid blocker, has been found to be generally well-tolerated in clinical trials, with no significant safety concerns identified 6.
It's worth noting that the side effects of Voquenza (peramivir) may be similar to those of other neuraminidase inhibitors, such as oseltamivir and zanamivir. However, without direct evidence, it's difficult to say for certain what the side effects of Voquenza are.