What are the side effects of Voquezna (vonoprazan)?

From the FDA Drug Label

What are the possible side effects of VOQUEZNA? VOQUEZNA may cause serious side effects, including: A type of kidney problem (acute tubulointerstitial nephritis). Diarrhea caused by an infection (Clostridioides difficile) in your intestines. Bone fractures (hip, wrist, or spine) Severe skin reactions Low Vitamin B-12 levels. Low magnesium levels in the body can happen in people who take VOQUEZNA. Stomach growths (fundic gland polyps) The most common side effects of VOQUEZNA for treatment of erosive esophagitis and/or relief of heartburn related to gastroesophageal reflux disease include: stomach inflammation diarrhea stomach bloating stomach pain nausea indigestion constipation high blood pressure urinary tract infection The most common side effect of VOQUEZNA when used with antibiotics for treatment of H pylori infection include: diarrhea temporary changes in sense of taste vaginal yeast infection stomach pain headache high blood pressure cold-like symptoms

The side effects of Voquezna (vonoprazan) include:

• Serious side effects:
  • Kidney problems
  • Diarrhea caused by infection
  • Bone fractures
  • Severe skin reactions
  • Low Vitamin B-12 levels
  • Low magnesium levels
  • Stomach growths
• Common side effects for treatment of erosive esophagitis and/or relief of heartburn:
  • Stomach inflammation
  • Diarrhea
  • Stomach bloating
  • Stomach pain
  • Nausea
  • Indigestion
  • Constipation
  • High blood pressure
  • Urinary tract infection
• Common side effects for treatment of H pylori infection:
  • Diarrhea
  • Temporary changes in sense of taste
  • Vaginal yeast infection
  • Stomach pain
  • Headache
  • High blood pressure
  • Cold-like symptoms 1 1

From the Research

Voquezna (vonoprazan) can cause several side effects, with the most common being abdominal pain, constipation, diarrhea, nausea, and dyspepsia. The side effects of Voquezna are generally well tolerated, as reported in a recent study published in 2025 2. Some patients may also experience other gastrointestinal symptoms.

Common Side Effects

• Abdominal pain
• Constipation
• Diarrhea
• Nausea
• Dyspepsia It's essential to note that vonoprazan works differently than traditional proton pump inhibitors as it's a potassium-competitive acid blocker (P-CAB) that reversibly binds to hydrogen-potassium ATPase enzymes, providing rapid and sustained acid suppression.

Less Common Side Effects

Less common side effects may include headaches, dizziness, or rash. If you experience any severe side effects while taking Voquezna, contact your healthcare provider immediately. It's also important to inform your doctor about all medications you're taking, as vonoprazan may interact with certain drugs. The typical dosage is 20 mg once daily, but your doctor will determine the appropriate dose based on your specific condition and treatment goals. A systematic review and meta-analysis published in 2023 found that vonoprazan had no significant increase in the incidence of adverse effects compared to proton pump inhibitors, except for a lower incidence of diarrhea or loose stools 3.