What are the most common side effects of Annovera (segesterone acetate and ethinyl estradiol) and their frequencies?

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From the Research

Annovera's most common side effects include headaches, nausea, vomiting, and vaginitis, as reported in the most recent study 1. These side effects are associated with the use of segesterone acetate and ethinyl estradiol, the hormones present in Annovera. The frequencies of these side effects are not explicitly stated in the provided evidence, but they are mentioned as common side effects of both the etonogestrel/ethinyl estradiol ring and the segesterone acetate/ethinyl estradiol ring 1. Other notable side effects that may occur with Annovera include breast tenderness/pain, abdominal pain, acne, and decreased libido, although the provided evidence does not specify the frequencies of these side effects for Annovera specifically. It is essential to note that while these side effects are common, not everyone experiences them, and many users tolerate Annovera well. Regular follow-up appointments with a healthcare provider can help manage any side effects that may occur.

Some key points to consider when using Annovera include:

  • The vaginal ring is a combination of hormonal contraceptives that suppress ovulation and create physiologic conditions unfavorable for pregnancy 1.
  • Annovera is designed to be used for up to one year (13 cycles), offering patients an effective, user-controlled option 2.
  • The addition of Annovera to the market expands the available options for pregnancy prevention and addresses unmet contraceptive needs 2.
  • Optimal contraceptive selection requires patient and clinician discussion of the patient's tolerance for risk of pregnancy, menstrual bleeding changes, other risks, and personal values and preferences 3.

If you experience severe side effects like persistent headaches, significant mood changes, or signs of blood clots (severe leg pain, chest pain, shortness of breath), contact your healthcare provider immediately 1.

References

Research

Advances in contraception: vaginal contraceptive rings.

Therapeutic advances in reproductive health, 2023

Research

New Contraception Update - Annovera, Phexxi, Slynd, and Twirla.

Current obstetrics and gynecology reports, 2022

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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