From the Research
Foods that can trigger an increase in cyclic adenosine monophosphate (cAMP) in the body include caffeine-containing foods, foods rich in forskolin, high-protein foods, and foods containing natural beta-adrenergic agonists. These foods work through various mechanisms to influence cAMP levels, such as inhibiting phosphodiesterase enzymes or directly activating adenylate cyclase. Some key examples include:
- Caffeine-containing foods like coffee, tea, chocolate, and some sodas, which inhibit phosphodiesterase enzymes that break down cAMP 1.
- Foods rich in forskolin, such as Coleus forskohlii root, which directly activate adenylate cyclase, the enzyme that produces cAMP.
- High-protein foods, which may increase cAMP through certain amino acids that activate G-protein coupled receptors.
- Foods containing natural beta-adrenergic agonists like synephrine found in bitter orange, which can stimulate cAMP production. Additionally, some spices like ginger and turmeric contain compounds that may influence cAMP levels. The mechanism behind cAMP's importance involves its role as a second messenger in cellular signaling, regulating processes like metabolism, hormone response, and inflammation 2. Consuming these foods in moderation as part of a balanced diet can potentially support cellular communication and metabolic processes, though individual responses may vary based on overall health status and genetic factors. It's also worth noting that while some studies suggest a relationship between xanthine derivatives (like caffeine and theophylline) and increased cAMP levels, the evidence is not always consistent, and the effects can depend on the specific compound, concentration, and duration of exposure 3, 4, 5.