From the FDA Drug Label
DOSAGE AND ADMINISTRATION Prior to initiating testosterone cypionate injection, confirm the diagnosis of hypogonadism by ensuring that serum testosterone concentrations have been measured in the morning on at least two separate days and that these serum testosterone concentrations are below the normal range. For replacement in the hypogonadal male, 50 to 400 mg should be administered every two to four weeks.
The recommended dosage for a Testoviron (testosterone) subcutaneous injection course is not directly stated in the label, as it specifies intramuscular use only. However, for replacement in the hypogonadal male, the suggested dosage is 50 to 400 mg administered every two to four weeks 1.
- The dosage is adjusted according to the patient's response and the appearance of adverse reactions.
- Key considerations include the patient's age, sex, diagnosis, chronological age, and skeletal age. Note that subcutaneous injection is not mentioned in the label, which recommends intramuscular injections given deep in the gluteal muscle.
From the Research
The recommended dosage for Testoviron (testosterone enanthate) when administered subcutaneously is typically 50-250mg per week, divided into 1-2 injections, as supported by the most recent and highest quality study 2. For testosterone replacement therapy (TRT), most patients start with 100-200mg weekly, while higher doses may be used for bodybuilding or gender-affirming care. Subcutaneous injections should be administered into fatty tissue using a short needle (25-30 gauge, 1/2-5/8 inch), rotating injection sites between the abdomen, thigh, or gluteal area to prevent tissue damage. Key considerations for treatment include:
- Treatment duration varies by purpose - lifelong for hypogonadism, 8-16 weeks for muscle-building cycles (followed by post-cycle therapy), or ongoing for gender-affirming care.
- Regular blood tests (every 3-6 months) are essential to monitor testosterone levels, hematocrit, estradiol, and liver function, as indicated by studies such as 3 and 4.
- Subcutaneous administration offers advantages over intramuscular injections including less pain, fewer fluctuations in hormone levels, and reduced risk of hitting blood vessels, as demonstrated in 2. Side effects may include injection site reactions, hormonal fluctuations, increased red blood cell production, and potential fertility impacts, so medical supervision is crucial throughout treatment, as noted in various studies including 5 and 4.