From the Guidelines
Bimatoprost, also known by the brand name Latisse, is primarily used for eyelash growth, but its off-label uses for skin conditions are still largely experimental and not FDA-approved. When considering the use of Bimatoprost for skin-related conditions, it's essential to weigh the potential benefits against the risks, particularly given the limited and sometimes conflicting evidence available 1. Some potential off-label uses of Bimatoprost for the skin include:
- Eyelash hypertrichosis, which has been observed as a side effect of topical treatment for open-angle glaucoma
- Treating eyebrow thinning by applying a small amount to the brow area daily
- Possibly addressing hyperpigmentation issues like melasma, although results are inconsistent and more research is needed The mechanism by which Bimatoprost works, extending the growth phase of hair follicles and stimulating melanin production in hair, suggests potential applications beyond eyelash growth, but these uses require further study to fully understand their efficacy and safety 1. Key considerations for using Bimatoprost on the skin include:
- Applying a tiny drop with a sterile applicator to the desired area once daily, usually at bedtime
- Potential side effects such as redness, itching, and darkening of surrounding skin
- The need for consultation with a dermatologist to guide application techniques and monitor for adverse effects Given the current state of evidence, it is crucial to approach the use of Bimatoprost for skin conditions with caution, prioritizing consultation with a dermatologist and careful consideration of the potential risks and benefits.
From the Research
Uses of Bimatoprost (Lumigan) or Latisse (Bimatoprost) for the Skin
- Bimatoprost is used to treat hypotrichosis of the eyelashes, increasing eyelash growth, including length, thickness, and darkness 2, 3.
- The medication is applied once daily to the skin of the upper eyelid margin using sterile single-use-per-eye applicators 2, 3.
- Bimatoprost has been shown to be effective in enhancing upper eyelash growth, with a favorable safety and tolerability profile when applied dermally 2, 3.
- In addition to its use for eyelash hypotrichosis, bimatoprost has been investigated for the treatment of eyebrow hypotrichosis, with studies suggesting its efficacy and safety for this indication 4.
- However, bimatoprost has also been associated with potential side effects, including periorbital hollowing due to fat atrophy, which can be irreversible 5.
Mechanism of Action
- Bimatoprost is believed to stimulate the prostaglandin receptor in dermal papilla and melanocyte, leading to a prolonged anagen phase and increased melanogenesis 4.
- This results in an increase in hair follicle thickness, length, and darkness 4.