From the FDA Drug Label
Apply a thin film of cream to affected area and gently rub in until fully absorbed. ... For best results, apply 3 to 4 times daily. The recommended frequency for applying capsaicin cream to a shingles rash is 3 to 4 times daily 1.
From the Research
Capsaicin cream should be applied 3-4 times daily to a shingles rash, as this frequency has been shown to provide significant pain relief in patients with post-herpetic neuralgia 2. The cream should be applied as a thin layer to the affected area, making sure to cover the entire rash but avoiding contact with broken skin, eyes, or mucous membranes. Before each application, ensure the previous application has been completely absorbed. Treatment should continue for at least 2-4 weeks to achieve maximum benefit, as capsaicin works by depleting substance P, a neurotransmitter involved in pain signaling. Some studies have reported good pain relief with capsaicin treatment, with 39% of patients achieving at least a good result and 55% showing improvement 3. However, it's essential to note that patients may experience a burning sensation upon initial applications, which typically diminishes with continued use. It's crucial to wash hands thoroughly after application to prevent accidental transfer to sensitive areas. If skin irritation becomes severe or symptoms worsen, discontinue use and consult a healthcare provider. Capsaicin cream serves as a complementary treatment to other shingles medications and can help manage post-herpetic neuralgia, the persistent pain that sometimes follows shingles. Key considerations for treatment include:
- Applying the cream 3-4 times daily
- Avoiding contact with sensitive areas
- Continuing treatment for at least 2-4 weeks
- Monitoring for skin irritation and discontinuing use if necessary
- Using capsaicin cream as a complementary treatment to other shingles medications.