From the Guidelines
Latanoprost (Latana pro) eyedrops for glaucoma should be refrigerated before opening, but can be stored at room temperature for up to 6 weeks after opening. The storage instructions for latanoprost are crucial to maintain the medication's stability and effectiveness 1. Unopened bottles must be kept in the refrigerator at 36°F to 46°F (2°C to 8°C) to prevent degradation of the medication. Once opened, the bottle can be kept at room temperature up to 77°F (25°C), but should be used within 6 weeks as the medication gradually loses potency after this time.
Key Storage Considerations
- Refrigeration before opening is necessary because latanoprost is sensitive to heat and light, which can cause the medication to degrade
- The preservatives in the solution provide limited protection once the bottle is opened
- When storing latanoprost at room temperature after opening, keep it away from direct sunlight and heat sources
- Remember to mark the date of opening on the bottle to track the 6-week use period, and discard any unused medication after this time even if solution remains. It is essential to follow these storage guidelines to ensure the medication remains effective in lowering intraocular pressure (IOP) in patients with glaucoma, as demonstrated in studies comparing the efficacy of different glaucoma interventions 1.
From the FDA Drug Label
Storage Protect from light. Store unopened bottle(s) under refrigeration at 2° to 8°C (36° to 46°F). Once a bottle is opened for use, it may be stored at room temperature up to 25°C (77°F) for 6 weeks.
Yes, Latana pro (Latanoprost) eyedrops for glaucoma require refrigeration when unopened. However, after opening, they can be stored at room temperature for up to 6 weeks 2.
From the Research
Storage Requirements for Latanoprost Eyedrops
- The storage requirements for Latanoprost (Latana pro) eyedrops are not explicitly stated in the provided studies as requiring refrigeration after opening 3, 4, 5, 6, 7.
- However, studies suggest that Latanoprost remains stable at room temperature, with one study finding that the concentration of Latanoprost in bottles stored at room temperature for 4 to 6 weeks remained within 90% to 110% of the labeled amount 4.
- Another study compared the efficacy of Latanoprost stored at 4°C and 30°C, finding no significant difference in intraocular pressure reduction between the two storage conditions 5.
- A study on the effect of temperature and light on the stability of Latanoprost found that it remained stable at 4°C and 25°C for up to 30 days, but degraded more quickly at higher temperatures and with exposure to ultraviolet radiation 6.
- It is recommended to store Latanoprost in a cool, dark place, but refrigeration after opening may not be necessary 4, 5, 6.