From the Guidelines
Lidocaine-prilocaine cream is unlikely to irritate hemorrhoids and may actually help relieve hemorrhoid pain. This topical anesthetic combination works by temporarily numbing the area, which can reduce pain, itching, and discomfort associated with hemorrhoids. When applied to the affected area, it blocks nerve signals that transmit pain sensations. For hemorrhoid use, a small amount can be applied to the external hemorrhoid area up to 3-4 times daily as needed for pain relief. The medication should not be used for more than 7 consecutive days without medical supervision. Most patients tolerate lidocaine-prilocaine well, though some may experience mild temporary burning or stinging upon application. If you experience worsening irritation, severe burning, or an allergic reaction (swelling, rash), discontinue use and consult a healthcare provider. For internal hemorrhoids, specialized hemorrhoid-specific products are more appropriate as standard lidocaine-prilocaine formulations are designed for external use only.
According to the american gastroenterological association medical position statement: diagnosis and treatment of hemorrhoids 1, the cornerstone of medical therapy for hemorrhoids is adequate intake of fiber and water, and topical corticosteroids and analgesics are useful for managing perianal skin irritation. However, this study does not specifically address the use of lidocaine-prilocaine cream for hemorrhoids.
Some key points to consider when using lidocaine-prilocaine cream for hemorrhoids include:
- Apply a small amount to the external hemorrhoid area up to 3-4 times daily as needed for pain relief
- Do not use for more than 7 consecutive days without medical supervision
- Discontinue use if you experience worsening irritation, severe burning, or an allergic reaction
- Specialized hemorrhoid-specific products are more appropriate for internal hemorrhoids.
It is essential to follow the recommended usage and precautions to minimize potential side effects and ensure effective pain relief. If you have any concerns or questions, consult a healthcare provider for personalized advice.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Lidocaine and Prilocaine Irritation of Hemorrhoids
- There is no direct evidence that lidocaine and prilocaine irritate hemorrhoids. However, several studies have investigated the use of these topical anesthetics in the treatment of hemorrhoids.
- A study published in 2008 2 found that topical EMLA cream (lidocaine 2.5% and prilocaine 2.5%) was effective in reducing postoperative pain after hemorrhoidectomy.
- Another study published in 2019 3 found that a medical preparation containing tribenoside + lidocaine was effective and safe for the symptomatic treatment of hemorrhoids in women.
- A 2023 study 4 found that topical lidocaine, with or without diltiazem, was effective in reducing pain after rubber band ligation of hemorrhoids.
- A review of clinical evidence published in 2016 5 found that the combination of tribenoside + lidocaine was a fast, effective, and safe option for the local treatment of low-grade hemorrhoids.
- An older study published in 1979 6 found that viscous lidocaine was a safe and effective analgesic for posthemorrhoidectomy pain.
Safety and Efficacy
- The studies suggest that lidocaine, with or without other ingredients, is safe and effective for the treatment of hemorrhoids.
- There is no evidence to suggest that lidocaine and prilocaine irritate hemorrhoids.
- However, it is essential to note that individual results may vary, and more research may be needed to fully understand the effects of these topical anesthetics on hemorrhoids.