From the Guidelines
The recommended dosing regimen for Cortisporin (neomycin and polymyxin B sulfates and hydrocortisone) otic drops is 3 to 4 drops instilled into the affected ear(s) three to four times daily. Before administration, the ear canal should be thoroughly cleaned and dried. For optimal results, the patient should lie with the affected ear upward, and after instilling the drops, remain in this position for 5 minutes to allow the medication to penetrate the ear canal. The typical treatment duration is 7 to 10 days, though this may vary based on the severity of the infection. It's essential not to touch the dropper to the ear or other surfaces to prevent contamination. Cortisporin works through multiple mechanisms: neomycin and polymyxin B are antibiotics that target different bacterial components to fight infection, while hydrocortisone reduces inflammation and associated symptoms like itching and swelling. If symptoms persist beyond 10 days or worsen, patients should consult their healthcare provider, as prolonged use may lead to fungal overgrowth or antibiotic resistance. None of the provided studies 1 directly address the dosing of Cortisporin otic drops, so the recommendation is based on general medical knowledge and the example provided.
From the Research
Cortisporin Drops Dosing Regimen
The dosing regimen for Cortisporin (neomycin and polymyxin B sulfates and hydrocortisone) drops is as follows:
- 3-4 drops, 3-4 times daily, for 7-10 days 2, 3
- 4 drops, 4 times daily, for 7-10 days (for adults) 2
- 2 drops, 4 times daily, for 7-10 days (for children) 2
- 3 drops, 4 times daily, for 7-10 days 4
Key Considerations
- The dosage and frequency of administration may vary depending on the specific condition being treated and the patient's response to therapy 4, 2, 3
- Cortisporin otic suspension is typically administered for 7-10 days, but the treatment duration may be adjusted based on the patient's clinical response 4, 2, 3
- It is essential to follow the recommended dosing regimen and treatment duration to ensure effective treatment and minimize the risk of adverse effects 4, 2, 3
Comparison with Other Treatments
- Cortisporin otic suspension has been compared to other topical antibiotic treatments, such as ofloxacin otic solution, in several studies 4, 5
- These studies have shown that Cortisporin otic suspension is effective in treating otitis externa, but may have a higher risk of ototoxicity compared to other treatments 4, 6