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Differential Diagnosis for Forefoot Pain

Single most likely diagnosis

  • Morton's Neuroma: This condition is characterized by a sharp, burning pain in the forefoot, often described as feeling like walking on pebbles or pingpong balls. It occurs due to the compression of the intermetatarsal nerve, typically between the third and fourth toes.

Other Likely diagnoses

  • Metatarsalgia: This refers to a general pain in the metatarsal region of the foot, which could be due to various reasons such as overuse, poor footwear, or abnormal foot mechanics. The pain can feel like walking on small, hard objects.
  • Sesamoiditis: Inflammation of the sesamoid bones under the first metatarsal head can cause pain in the forefoot, especially when bearing weight. The pain might be described as feeling like walking on small, hard objects.
  • Intermetatarsal Bursitis: Inflammation of the bursae between the metatarsals can cause pain and discomfort in the forefoot, potentially feeling like walking on small objects.

Do Not Miss diagnoses

  • Diabetic Neuropathy: Although less likely to present with such a specific symptom, diabetic neuropathy can cause a variety of sensations in the feet, including pain, numbness, or strange sensations like walking on objects. Missing this diagnosis could lead to significant morbidity.
  • Tumor (e.g., Glomus Tumor): Rarely, a tumor in the foot could cause localized pain and unusual sensations. Although unlikely, missing a tumor could have serious consequences.

Rare diagnoses

  • Freiberg's Disease: A rare condition that affects the metatarsal heads, causing pain and discomfort in the forefoot. It's more common in adolescents and young adults.
  • Gout or Pseudogout: Although these conditions typically affect the big toe, they can occasionally cause pain in other parts of the foot, including the forefoot, and might be described in unusual terms by patients.
  • Complex Regional Pain Syndrome (CRPS): A chronic pain condition that can cause severe, burning pain in one of the limbs, including the foot. The pain can be out of proportion to the injury and might include strange sensations.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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