From the Guidelines
Mometasone is an effective treatment for various inflammatory skin conditions, including eczema, psoriasis, dermatitis, and allergic rashes, as supported by recent guidelines and studies 1.
Key Points to Consider
- Mometasone furoate is a medium-to-high potency corticosteroid that can be used to treat inflammatory skin conditions, with a typical strength of 0.1% in cream, ointment, or lotion form.
- Treatment duration varies by condition, but generally ranges from 1-3 weeks for acute flares, with longer courses requiring medical supervision to avoid side effects 1.
- For facial or genital areas, use with caution and for shorter periods due to increased absorption and risk of skin thinning, as noted in guidelines for managing contact dermatitis and psoriasis 1.
- Mometasone works by reducing inflammation, suppressing immune responses, and constricting blood vessels in the skin, making it an effective option for managing symptoms of atopic dermatitis and other inflammatory skin conditions 1.
Important Considerations for Use
- Side effects may include skin thinning, stretch marks, increased infection risk, and adrenal suppression with prolonged use over large areas, highlighting the need for careful patient instruction and monitoring 1.
- Always wash hands after application unless treating the hands themselves, and avoid covering treated areas with occlusive dressings unless specifically directed by a healthcare provider, to minimize the risk of adverse effects 1.
- Recent guidelines, such as those from the Taiwan Academy of Pediatric Allergy, Asthma and Immunology, support the use of mometasone as part of a proactive therapy approach to prevent relapses in children with moderate to severe atopic dermatitis 1.
From the FDA Drug Label
The safety and efficacy of mometasone furoate ointment, 0.1% for the treatment of corticosteroid-responsive dermatoses was demonstrated in two vehicle-controlled trials, one in psoriasis and one in atopic dermatitis.
Mometasone is effective for treating certain skin conditions, including psoriasis and atopic dermatitis, as demonstrated by two vehicle-controlled trials 2. The drug has anti-inflammatory, antipruritic, and vasoconstrictive properties 2. Key points about its effectiveness include:
- Demonstrated efficacy in treating corticosteroid-responsive dermatoses
- Shown to be effective in trials for psoriasis and atopic dermatitis
- Has a medium range of potency compared to other topical corticosteroids 2
From the Research
Efficacy of Mometasone
- Mometasone is effective in treating various skin conditions, including atopic dermatitis, seborrhoeic dermatitis, scalp psoriasis, and psoriasis vulgaris 3, 4, 5, 6, 7
- It has been shown to be as effective as other glucocorticoids of similar potency, such as betamethasone dipropionate and methylprednisolone aceponate 3
- Mometasone has a rapid onset of action, with significant improvement in disease signs and symptoms within 1-2 weeks of treatment 3, 6
Safety and Tolerability
- Mometasone has a low potential for causing adverse systemic effects, such as suppression of the hypothalamic-pituitary-adrenal (HPA) axis 3, 5
- It has a low risk of primary sensitisation and cross-reactions with other topical glucocorticoids 3
- Local adverse effects, such as burning, stinging, and skin atrophy, are minimal and usually transient 3, 4, 5, 6
- Mometasone has been shown to be safe and effective for long-term treatment of atopic dermatitis, with minimal risk of skin atrophy 7
Comparison with Other Treatments
- Mometasone has been compared with other topical glucocorticoids, such as fluocinolone acetonide and triamcinolone acetonide, and has been shown to be more effective or equally effective 4
- It has also been compared with betamethasone valerate and has been shown to be as effective, with the added convenience of once-daily application 6