From the Research
The recommended dosage of triamcinolone for injection into the bladder for interstitial cystitis treatment is 40 mg of triamcinolone acetonide, as used in the study by 1, which demonstrated significant improvement in symptoms and quality of life in patients with type II/III interstitial cystitis/bladder pain syndrome.
Key Points
- The dosage of 40 mg of triamcinolone acetonide is based on the most recent and highest quality study available, which was published in 2020 by 1.
- This study found that submucosal injection of triamcinolone acetonide improved clinical symptoms and quality of life in both men and women with type II/III interstitial cystitis/bladder pain syndrome.
- The procedure typically involves diluting the medication in sterile saline or water, instilling it into the bladder via catheter, and having the patient retain the solution for a period of time before voiding.
- Patients should be monitored for potential side effects, including urinary tract infections, systemic absorption of steroids, and bladder irritation.
- This treatment is generally considered second or third-line therapy after more established treatments have failed, and should be performed by specialists experienced in managing interstitial cystitis.
Considerations
- The study by 2 also used a similar dosage of triamcinolone acetonide, with 10 ml of triamcinolone acetonide (40 mg/ml) injected into the submucosal space of the center and periphery of ulcers.
- However, the study by 3 found that the addition of triamcinolone acetonide to a standard bladder instillation solution did not improve symptoms associated with interstitial cystitis-bladder pain syndrome.
- The study by 1 is the most recent and highest quality study available, and its findings should be given the most weight in determining the recommended dosage of triamcinolone for injection into the bladder for interstitial cystitis treatment.