From the FDA Drug Label
adults and children 12 years and over take 2 caplets every 6 hours while symptoms last do not take more than 6 caplets in 24 hours, unless directed by a doctor Liver warning: ... Severe liver damage may occur if you take more than 4,000 mg of acetaminophen in 24 hours ...
The maximum recommended dose of Tylenol (acetaminophen) for an adult in a 24-hour period is not to exceed 6 caplets in 24 hours or 4,000 mg in 24 hours, unless directed by a doctor 1 1.
From the Research
The maximum recommended dose of Tylenol (acetaminophen) for a healthy adult is 3,000 mg (3 grams) in a 24-hour period, which typically means no more than 650 mg every 6 hours or 500 mg every 4 hours. This recommendation is based on the most recent and highest quality study available, which suggests that exceeding the recommended dose can cause severe liver damage, which may be irreversible and potentially fatal 2. When taking acetaminophen, it's essential to check all other medications you're using, as many combination products (cold medicines, sleep aids, and prescription pain relievers) also contain acetaminophen, which could lead to unintentional overdose. Some key points to consider when taking acetaminophen include:
- Always follow the dosing instructions on the package or as directed by your healthcare provider
- Never take more than the recommended amount even if pain persists
- Be aware of the potential for liver damage, especially for people with liver disease, those who regularly consume alcohol, or elderly individuals, who may need to take even lower doses 3, 4
- A sustained-release formulation of acetaminophen may be a convenient option for chronic users, but its safety and pharmacokinetics should be evaluated carefully 5. It's crucial to prioritize caution when taking acetaminophen, as the risks associated with overdose can be severe and potentially life-threatening.