From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
The injection volume for semaglutide at a dose of 0.1mg using a 2.5mg/ml concentration is 0.04ml. To calculate this volume, I divided the desired dose (0.1mg) by the concentration (2.5mg/ml), which equals 0.04ml. This small volume should be administered subcutaneously using an appropriate insulin syringe that can accurately measure such small volumes, typically a 0.3ml or 0.5ml syringe with fine gradations. When administering semaglutide, it's essential to rotate injection sites between the abdomen, thigh, or upper arm to prevent lipohypertrophy, as noted in various studies, including those on the pharmacokinetics and clinical implications of semaglutide 1. The medication should be inspected before use to ensure it is clear and colorless. Semaglutide works by mimicking the incretin hormone GLP-1, which stimulates insulin secretion, suppresses glucagon secretion, and slows gastric emptying, helping to lower blood glucose levels and potentially assist with weight management, as discussed in the context of its efficacy and safety in clinical trials 2, 3, 4, 5. Given the most recent and highest quality evidence, the recommended injection volume of 0.04ml for a 0.1mg dose of semaglutide at a concentration of 2.5mg/ml is based on straightforward calculation and is supported by the understanding of semaglutide's mechanism of action and its use in clinical practice.