From the Research
Nystatin-triamcinolone ointment is typically applied to affected skin areas 2-3 times daily for 7-14 days to treat fungal skin infections with inflammation. Apply a thin layer to clean, dry skin and gently rub in until absorbed, covering the infected area and a small margin of surrounding healthy skin. This combination medication works through nystatin, which kills fungi by binding to their cell membranes, while triamcinolone reduces inflammation, redness, and itching.
Key Considerations
- Treatment should continue for at least 48 hours after symptoms resolve to prevent recurrence.
- Discontinue use and consult a healthcare provider if irritation develops or if the infection worsens or persists beyond two weeks.
- This medication should not be used on children under 2 years without medical supervision, and it should be avoided on the face, groin, or axillae unless specifically directed by a healthcare provider.
- The medication should not be covered with occlusive dressings unless prescribed, as this may increase absorption and side effect risk. According to a study published in 2013 1, a novel nystatin nanoemulsion has shown potential for skin candidosis infections, with improved therapeutic index and antifungal effect compared to commercial ointments. However, the most relevant and recent study for the use of nystatin-triamcinolone ointment is from 1977 2, which compared nystatin cream with nystatin/triamcinolone acetonide combination cream in the treatment of candidal inflammation of the flexures, finding both treatments equally effective.
Administration and Monitoring
- Apply a thin layer to the affected area and gently rub in until absorbed.
- Cover the infected area and a small margin of surrounding healthy skin.
- Monitor for signs of irritation, infection worsening, or persistence beyond two weeks. Other studies, such as those from 1999 3 and 2012 4, provide information on the use of nystatin in different contexts, but are not directly relevant to the recommended use and dosage of nystatin-triamcinolone ointment for fungal skin infections. A study from 1999 5 compared mupirocin and nystatin in the treatment of diaper candidosis, finding both effective but with different responses. However, the most recent and highest quality study relevant to the question is from 2013 1, which evaluated a novel nystatin nanoemulsion for skin candidosis infections.