From the Research
No, you should not take Vyvanse (lisdexamfetamine) and Phentermine together as this combination is potentially dangerous. Both medications are stimulants that increase central nervous system activity, and taking them simultaneously can lead to additive effects that significantly increase the risk of serious side effects. The combination can cause dangerous elevations in blood pressure, heart rate, and body temperature, potentially leading to cardiovascular problems such as arrhythmias, heart attack, or stroke. Additionally, this combination may increase the risk of psychiatric side effects including severe anxiety, agitation, and psychosis. Both medications affect similar neurotransmitters (primarily dopamine and norepinephrine), and their combined action can overwhelm your system. If you're currently taking one of these medications and considering the other, you should consult with your healthcare provider about alternative options. Never combine these medications without explicit medical supervision, and always disclose all medications you're taking to your healthcare providers to avoid potentially harmful drug interactions, as suggested by a study on potential drug-drug interactions with phentermine 1. It's also important to consider the pharmacological properties of lisdexamfetamine, which is a prodrug that is hydrolyzed to its active form d-amphetamine in the blood following oral administration, as described in a study on the pharmacological properties and clinical effects of lisdexamfetamine 2. Furthermore, the medical treatment of attention deficit hyperactivity disorder (ADHD) with amphetamines, including lisdexamfetamine, should be carefully considered due to the potential for abuse and addiction, as discussed in a study on the medical treatment of ADHD with amphetamines 3. Other studies have also highlighted the importance of careful consideration when prescribing lisdexamfetamine, including its reduced abuse potential compared to other stimulants 4, 5. In summary, the combination of Vyvanse and Phentermine is not recommended due to the potential for serious side effects and the importance of careful consideration when prescribing these medications.